2-Methylsulfonyl-4,6-dichloro-5-ethylpyriMidine

Base Information

• Chemical Name: 2-Methylsulfonyl-4,6-dichloro-5-ethylpyriMidine
• CAS No.: 1263314-16-4
• Molecular Formula: C₇H₈Cl₂N₂O₂S
• Molecular Weight: 255.125
• Mol file: 1263314-16-4.mol

Synonyms:

Chemical Property of 2-Methylsulfonyl-4,6-dichloro-5-ethylpyriMidine

Chemical Property:

• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

4,6-Dichloro-5-ethyl-2-(methylsulfonyl)pyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Methylsulfonyl-4,6-dichloro-5-ethylpyriMidine

There total 3 articles about 2-Methylsulfonyl-4,6-dichloro-5-ethylpyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4,6-dichloro-5-ethyl-2-(methylthio)pyrimidine → 4,6-dichloro-5-ethyl-2-(methylsulfonyl)pyrimidine (1263314-16-4)

Guidance literature:

With potassium peroxymonosulfate sulfate; tetrabutylammomium bromide; In water; acetone; at 20 ℃;

DOI:10.1080/00397911.2017.1421664

Reference yield:

ethyl diethyl malonate (133-13-1) → 4,6-dichloro-5-ethyl-2-(methylsulfonyl)pyrimidine (1263314-16-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol / 4 h / Reflux

2: trichlorophosphate; triethylamine / 3 h / Reflux

3: tetrabutylammomium bromide; potassium peroxymonosulfate sulfate / acetone; water / 20 °C

With potassium peroxymonosulfate sulfate; tetrabutylammomium bromide; triethylamine; sodium hydroxide; trichlorophosphate; In ethanol; water; acetone;

DOI:10.1080/00397911.2017.1421664

Reference yield:

C7H10N2O2S → 4,6-dichloro-5-ethyl-2-(methylsulfonyl)pyrimidine (1263314-16-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trichlorophosphate; triethylamine / 3 h / Reflux

2: tetrabutylammomium bromide; potassium peroxymonosulfate sulfate / acetone; water / 20 °C

With potassium peroxymonosulfate sulfate; tetrabutylammomium bromide; triethylamine; trichlorophosphate; In water; acetone;

DOI:10.1080/00397911.2017.1421664

upstream raw materials:

ethyl diethyl malonate

Refernces