2-(Piperidin-4-YL)benzonitrile hydrochloride

Base Information

Chemical Name:2-(Piperidin-4-YL)benzonitrile hydrochloride
CAS No.:256951-73-2
Molecular Formula:C₁₂H₁₄N₂*ClH
Molecular Weight:222.718
Hs Code.:2933399990
European Community (EC) Number:894-663-0
Mol file:256951-73-2.mol

Synonyms:2-(PIPERIDIN-4-YL)BENZONITRILE HYDROCHLORIDE;256951-73-2;2-piperidin-4-ylbenzonitrile;hydrochloride;2-(4-piperidyl)benzenecarbonitrile hydrochloride;starbld0019614;SCHEMBL4739383;TQP0513;YRJLDXCKPQNHNB-UHFFFAOYSA-N;2-(4-piperidyl)benzenecarbonitrile HCl;DA-27602;2-(piperidin-4-yl) benzonitrile hydrochloride;EN300-18680015

Suppliers and Price of 2-(Piperidin-4-YL)benzonitrile hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-(Piperidin-4-yl)benzonitrilehydrochloride 97%
1 g
$ 3520.00

SynQuest Laboratories
2-(Piperidin-4-yl)benzonitrilehydrochloride 97%
500 mg
$ 2240.00

SynQuest Laboratories
2-(Piperidin-4-yl)benzonitrilehydrochloride 97%
100 mg
$ 800.00

Total 12 raw suppliers

Chemical Property of 2-(Piperidin-4-YL)benzonitrile hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:222.0923762
Heavy Atom Count:15
Complexity:222

Purity/Quality:

99%, ^*data from raw suppliers

2-(Piperidin-4-yl)benzonitrilehydrochloride 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CNCCC1C2=CC=CC=C2C#N.Cl

Technology Process of 2-(Piperidin-4-YL)benzonitrile hydrochloride

There total 5 articles about 2-(Piperidin-4-YL)benzonitrile hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 256951-72-1
tert-butyl 4-(2-cyanophenyl)piperidine-1-carboxylate

: 256951-73-2
2-(piperidin-4-yl)benzonitrile hydrochloride

Guidance literature:: With hydrogenchloride; In ethyl acetate; at 0 ℃; for 0.166667h;
DOI:10.1021/jm990612y

Reference yield:

: 194669-38-0
2-[1-tert-butoxycarbonyl-(1.2.3.6-tetrahydropyridin-4-yl)]benzonitrile

: 256951-73-2
2-(piperidin-4-yl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / H₂; AcOH / 10percent Pd/C / ethanol / 15 h / 2585.81 Torr

2: 100 percent / HCl(g) / ethyl acetate / 0.17 h / 0 °C

With hydrogenchloride; hydrogen; acetic acid; 10percent Pd/C; In ethanol; ethyl acetate; 1: Catalytic hydrogenation / 2: Acidolysis;
DOI:10.1021/jm990612y

Reference yield:

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 256951-73-2
2-(piperidin-4-yl)benzonitrile hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / Pd(PPh₃)4 / tetrahydrofuran / 0.5 h / 20 °C

2: 91 percent / H₂; AcOH / 10percent Pd/C / ethanol / 15 h / 2585.81 Torr

3: 100 percent / HCl(g) / ethyl acetate / 0.17 h / 0 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; acetic acid; 10percent Pd/C; In tetrahydrofuran; ethanol; ethyl acetate; 1: Arylation / 2: Catalytic hydrogenation / 3: Acidolysis;
DOI:10.1021/jm990612y