5-METHYL-3-PYRROLIDIN-2-YLISOXAZOLE

Base Information

• Chemical Name: 5-METHYL-3-PYRROLIDIN-2-YLISOXAZOLE
• CAS No.: 1000932-34-2
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.196
• Mol file: 1000932-34-2.mol

Synonyms:5-methyl-3-pyrrolidin-2-ylisoxazole;

Chemical Property of 5-METHYL-3-PYRROLIDIN-2-YLISOXAZOLE

Chemical Property:

• PSA: 38.06000
• LogP: 1.73630

Purity/Quality:

98%min ^*data from raw suppliers

5-Methyl-3-(pyrrolidin-2-yl)-1,2-oxazole ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-METHYL-3-PYRROLIDIN-2-YLISOXAZOLE

There total 1 articles about 5-METHYL-3-PYRROLIDIN-2-YLISOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

5-methyl-3-(N-(tert-butyloxycarbonyl)-2(S)-pyrrolidinyl)isoxazole → 5-Methyl-3-(S)-pyrrolidin-2-yl-isoxazole (1000932-34-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2009.12.085

Reference yield:

7-(3,4-Dichlorophenyl)-4,7-dihydro-5-methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid (343240-67-5) + 5-Methyl-3-(S)-pyrrolidin-2-yl-isoxazole (1000932-34-2) → C22H21Cl2N5O2

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane;

DOI:10.1016/j.bmcl.2009.12.085

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 5-Methyl-3-(S)-pyrrolidin-2-yl-isoxazole (1000932-34-2) → (S)-5-methyl-3-(1-methylpyrrolidin-2-yl)isoxazole (161423-38-7)

Guidance literature:

With formic acid; for 1h; Yield given; Heating;

DOI:10.1021/jm00052a005

Downstream raw materials:

(S)-5-methyl-3-(1-methylpyrrolidin-2-yl)isoxazole

Refernces

• 1、 Lloyd, John,Finlay, Heather J.,Vacarro, Wayne,Hyunh, Tram,Kover, Alexander,Bhandaru, Rao,Yan, Lin,Atwal, Karnail,Conder, Mary Lee,Jenkins-West, Tonya,Shi, Hong,Huang, Christine,Li, Danshi,Sun, Huabin,Levesque, Paul. "Pyrrolidine amides of pyrazolodihydropyrimidines as potent and selective KV1.5 blockers". scheme or table. p. 1436 - 1439. Retrieved 2010/07/02.