(R)-2-Amino-7-hydroxytetralin

Base Information

• Chemical Name: (R)-2-Amino-7-hydroxytetralin
• CAS No.: 85951-61-7
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.219
• Hs Code.: 2922299090
• European Community (EC) Number: 684-990-5
• DSSTox Substance ID: DTXSID00563625
• Wikidata: Q72438102
• Mol file: 85951-61-7.mol

Synonyms:(R)-2-Amino-7-hydroxytetralin;85951-61-7;(7R)-7-amino-5,6,7,8-tetrahydronaphthalen-2-ol;(3R)-3-Aminotetralin-6-ol;(R)-2-Amino-7-Hydroxytetraline;(R)-7-Amino-5,6,7,8-tetrahydro-naphthalen-2-ol;MFCD11617807;(R)-7-amino-5,6,7,8-tetrahydronaphthalen-2-ol;SCHEMBL9135070;DTXSID00563625;AKOS006317181;AKOS015854161;MS-22704;AM20120605;CS-0330873;A863376

Chemical Property of (R)-2-Amino-7-hydroxytetralin

Chemical Property:

• Melting Point: 143-144 °C
• Boiling Point: 325.1±42.0 °C(Predicted)
• PKA: 10.21±0.20(Predicted)
• PSA: 46.25000
• Density: 1.147±0.06 g/cm3(Predicted)
• LogP: 1.90850
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 163.099714038
• Heavy Atom Count: 12
• Complexity: 160

Purity/Quality:

98% ^*data from raw suppliers

(R)-7-Amino-5,6,7,8-tetrahydro-naphthalen-2-ol 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=C(CC1N)C=C(C=C2)O
• Isomeric SMILES: C1CC2=C(C[C@@H]1N)C=C(C=C2)O

Technology Process of (R)-2-Amino-7-hydroxytetralin

There total 3 articles about (R)-2-Amino-7-hydroxytetralin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

(2R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine (121216-43-1,118298-16-1) → (+)-7-OH-AT (85951-61-7)

Guidance literature:

With ammonium hydroxide; hydrogen bromide; for 3h; Heating;

DOI:10.1016/0223-5234(94)90095-7

Reference yield:

2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene (4003-89-8,118298-16-1) → (+)-7-OH-AT (85951-61-7)

Guidance literature:

Multi-step reaction with 2 steps

2: 30 percent / 1.) 48percent HBr aq., 2.) NH₄OH / 3 h / Heating

With ammonium hydroxide; hydrogen bromide;

DOI:10.1016/0223-5234(94)90095-7

Reference yield:

→ (+)-7-OH-AT (85951-61-7)

Guidance literature:

upstream raw materials:

(2R)-7-methoxy-1,2,3,4-tetrahydronaphthalen-2-amine

2-amino-7-methoxy-1,2,3,4-tetrahydronaphthalene

Downstream raw materials:

(+)-N-<(2R)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(S)-mandelamide

(+)-N-<(2R)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(S)-3-chloromandelamide

(+)-N-<(2R)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(R)-3-chloromandelamide

N-<(2R)-7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl>-(2R)-2-(3-chlorphenyl)-2-hydroxyethanamine