(1R)-3-{(1R)-3-[(9H-fluoren-9-yl)methoxy]-1-methyl-3-oxopropoxy}-1-methyl-3-oxopropyl (4R,8R,22R,26R)-31-({[(tert-butyl)diphenylsilyl]oxy}methyl)-4,8,22,26-tetramethyl-2,6,10,20,24,28-hexaoxo-3,7,11,19,23,27-hexaoxatricyclo[27.3.1.1^13.17]tetratriac...

Base Information

• Chemical Name: (1R)-3-{(1R)-3-[(9H-fluoren-9-yl)methoxy]-1-methyl-3-oxopropoxy}-1-methyl-3-oxopropyl (4R,8R,22R,26R)-31-({[(tert-butyl)diphenylsilyl]oxy}methyl)-4,8,22,26-tetramethyl-2,6,10,20,24,28-hexaoxo-3,7,11,19,23,27-hexaoxatricyclo[27.3.1.1^13.17]tetratriac...
• CAS No.: 193953-35-4
• Molecular Formula: C₇₂H₇₈O₁₉Si
• Molecular Weight: 1275.49

Synonyms:

Chemical Property of (1R)-3-{(1R)-3-[(9H-fluoren-9-yl)methoxy]-1-methyl-3-oxopropoxy}-1-methyl-3-oxopropyl (4R,8R,22R,26R)-31-({[(tert-butyl)diphenylsilyl]oxy}methyl)-4,8,22,26-tetramethyl-2,6,10,20,24,28-hexaoxo-3,7,11,19,23,27-hexaoxatricyclo[27.3.1.1^13.17]tetratriac...

Chemical Property:

Purity/Quality:

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Useful:

Technology Process of (1R)-3-{(1R)-3-[(9H-fluoren-9-yl)methoxy]-1-methyl-3-oxopropoxy}-1-methyl-3-oxopropyl (4R,8R,22R,26R)-31-({[(tert-butyl)diphenylsilyl]oxy}methyl)-4,8,22,26-tetramethyl-2,6,10,20,24,28-hexaoxo-3,7,11,19,23,27-hexaoxatricyclo[27.3.1.1^13.17]tetratriac...

There total 18 articles about (1R)-3-{(1R)-3-[(9H-fluoren-9-yl)methoxy]-1-methyl-3-oxopropoxy}-1-methyl-3-oxopropyl (4R,8R,22R,26R)-31-({[(tert-butyl)diphenylsilyl]oxy}methyl)-4,8,22,26-tetramethyl-2,6,10,20,24,28-hexaoxo-3,7,11,19,23,27-hexaoxatricyclo[27.3.1.1^13.17]tetratriac... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3,5-tris-(methoxycarbonyl)benzene (2672-58-4) → (1R)-3-{(1R)-3-[(9H-fluoren-9-yl)methoxy]-1-methyl-3-oxopropoxy}-1-methyl-3-oxopropyl (4R,8R,22R,26R)-31-({[(tert-butyl)diphenylsilyl]oxy}methyl)-4,8,22,26-tetramethyl-2,6,10,20,24,28-hexaoxo-3,7,11,19,23,27-hexaoxatricyclo[27.3.1.113.17]tetratriac... (193953-35-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 23 percent / LiAlH₄ / tetrahydrofuran / 0.17 h / 1 - 30 °C

2: KOH / methanol

3: (i-Pr)2NH / dimethylformamide / 24 h / Ambient temperature

4: 81 percent / 1 N KOH / ethanol; H₂O / 0.33 h / Ambient temperature

5: oxalyl chloride / CH₂Cl₂; dimethylformamide / Ambient temperature

6: pyridine / CH₂Cl₂ / 0 °C / to RT

7: 98 percent / HF*pyridine / CH₂Cl₂ / 0.25 h / 0 °C

8: pyridine / CH₂Cl₂ / -78 deg C, 5 h, RT, 36 h

With pyridine; potassium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; pyridine hydrogenfluoride; diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19970800402

Reference yield:

dimethyl 5-hydroxymethylbenzene-1,3-dicarboxylate (109862-53-5) → (1R)-3-{(1R)-3-[(9H-fluoren-9-yl)methoxy]-1-methyl-3-oxopropoxy}-1-methyl-3-oxopropyl (4R,8R,22R,26R)-31-({[(tert-butyl)diphenylsilyl]oxy}methyl)-4,8,22,26-tetramethyl-2,6,10,20,24,28-hexaoxo-3,7,11,19,23,27-hexaoxatricyclo[27.3.1.113.17]tetratriac... (193953-35-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 92.8 percent / DMAP / dimethylformamide / 24 h / Ambient temperature

2: 78 percent / LiOH / methanol; dioxane; H₂O / 0.5 h

3: (COCl)2 / dimethylformamide / 14 h

4: pyridine, (t-Bu)Ph₂SiF / CH₂Cl₂ / 0 deg C, 3 h, RT, 8 h

5: 98 percent / H₂ / 10 percent Pd/C / various solvent(s)

6: oxalyl chloride / CH₂Cl₂ / Ambient temperature

7: pyridine / CH₂Cl₂ / -78 deg C, 5 h, RT, 36 h

With pyridine; dmap; lithium hydroxide; oxalyl dichloride; hydrogen; tert-butyl diphenylfluorosilane; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19970800402

Reference yield:

5-(tert-Butyl-diphenyl-silanyloxymethyl)-isophthalic acid (193953-06-9) → (1R)-3-{(1R)-3-[(9H-fluoren-9-yl)methoxy]-1-methyl-3-oxopropoxy}-1-methyl-3-oxopropyl (4R,8R,22R,26R)-31-({[(tert-butyl)diphenylsilyl]oxy}methyl)-4,8,22,26-tetramethyl-2,6,10,20,24,28-hexaoxo-3,7,11,19,23,27-hexaoxatricyclo[27.3.1.113.17]tetratriac... (193953-35-4)

Guidance literature:

Multi-step reaction with 5 steps

1: (COCl)2 / dimethylformamide / 14 h

2: pyridine, (t-Bu)Ph₂SiF / CH₂Cl₂ / 0 deg C, 3 h, RT, 8 h

3: 98 percent / H₂ / 10 percent Pd/C / various solvent(s)

4: oxalyl chloride / CH₂Cl₂ / Ambient temperature

5: pyridine / CH₂Cl₂ / -78 deg C, 5 h, RT, 36 h

With pyridine; oxalyl dichloride; hydrogen; tert-butyl diphenylfluorosilane; palladium on activated charcoal; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.19970800402

upstream raw materials:

3,5-Bis-hydroxymethyl-benzoic acid (R)-2-[(R)-2-(9H-fluoren-9-ylmethoxycarbonyl)-1-methyl-ethoxycarbonyl]-1-methyl-ethyl ester

1,3,5-tris-(methoxycarbonyl)benzene

3,5-bis(hydroxylmethyl)benzoic acid methyl ester

dimethyl 5-hydroxymethylbenzene-1,3-dicarboxylate

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