9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

Base Information

• Chemical Name: 9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one
• CAS No.: 1169699-64-2
• Molecular Formula: C15H20N2O2
• Molecular Weight: 260.3315
• Hs Code.: 2934999090
• Mol file: 1169699-64-2.mol

Synonyms:9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one;9-(phenylMethyl)-1-Oxa-4,9-diazaspiro[5.5]undecan-3-one;1-Oxa-4,9-diazaspiro[5.5]undecan-3-one, 9-(phenylMethyl)-

Chemical Property of 9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

Chemical Property:

• Boiling Point: 461.2±45.0 °C(Predicted)
• PKA: 14.85±0.20(Predicted)
• PSA: 45.06000
• Density: 1.19±0.1 g/cm3(Predicted)
• LogP: 1.38140
• Storage Temp.: 2-8°C

Purity/Quality:

99.3% ^*data from raw suppliers

9-Benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one

There total 5 articles about 9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]-2-chloroacetamide (1169699-63-1) → 9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one (1169699-64-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1h; Inert atmosphere;

Reference yield:

4-(aminomethyl)-1-benzyl-4-hydroxypiperidine (23804-68-4) → 9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one (1169699-64-2)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 0.92 h / 0 °C / Inert atmosphere

2: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane; mineral oil; 1: |Schotten-Baumann Reaction;

Reference yield:

N-benzyl-1-oxa-6-azaspiro[2,5]-octane (19867-34-6) → 9-benzyl-1-oxa-4,9-diazaspiro[5.5]undecan-3-one (1169699-64-2)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium hydroxide / methanol; water / 0 - 20 °C

2: triethylamine / dichloromethane / 0.92 h / 0 °C / Inert atmosphere

3: sodium hydride / mineral oil; tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

With ammonium hydroxide; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water; mineral oil; 2: |Schotten-Baumann Reaction;

upstream raw materials:

1-phenylmethyl-4-piperidone

4-(aminomethyl)-1-benzyl-4-hydroxypiperidine

N-benzyl-1-oxa-6-azaspiro[2,5]-octane

N-[(1-benzyl-4-hydroxypiperidin-4-yl)methyl]-2-chloroacetamide

Refernces

• 1、 -. "2-[BIS(4-FLUOROPHENYL)METHYL]-2,7-DIAZASPIRO[4.5]DECAN-10-ONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HUMAN DOPAMINE-ACTIVE-TRANSPORTER (DAT) PROTEIN FOR THE TREATMENT OF E.G. ATTENTION DEFICIT DISORDER (ADD)". . . Retrieved 2016/04/09.