4-(Bromoacetyl)morpholine

Base Information

• Chemical Name: 4-(Bromoacetyl)morpholine
• CAS No.: 40299-87-4
• Molecular Formula: C6H10BrNO2
• Molecular Weight: 208.055
• Hs Code.: 2934999090
• European Community (EC) Number: 805-089-7
• DSSTox Substance ID: DTXSID50553930
• Nikkaji Number: J2.463.658E
• Wikidata: Q72451281
• Mol file: 40299-87-4.mol

Synonyms:40299-87-4;4-(BROMOACETYL)MORPHOLINE;2-Bromo-1-morpholinoethanone;2-bromo-1-morpholin-4-ylethanone;2-bromo-1-(morpholin-4-yl)ethanone;2-Bromo-1-(morpholin-4-yl)ethan-1-one;2-BROMO-1-(4-MORPHOLINYL)ETHANONE;4-(2-Bromoacetyl)morpholine;MFCD06800306;2-Bromo-1-Morpholin-4-Yl-Ethanone;MORPHOLINE, 4-(BROMOACETYL)-;C6H10BrNO2;Bromoacetylmorpholine;4-bromoacetylmorpholine;N-bromoacetyl-morpholine;4-bromoacetyl morpholine;4-(bromoacetyl) morpholine;N-(2-bromoacetyl)-morpholine;SCHEMBL311608;4-(alpha-Bromoacetyl)morpholine;2-bromo-1-morpholino-1-ethanone;DTXSID50553930;LLLQAMNGYJQUKK-UHFFFAOYSA-N;4-(2-bromo-1-oxoethyl)morpholine;4-(Bromoacetyl)morpholine, AldrichCPR;AKOS000500340;AB29971;s10967;AS-61254;BP-13110;SY079349;CS-0139505;EN300-1241327;A873382;F3310-0728

Chemical Property of 4-(Bromoacetyl)morpholine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.522
• Boiling Point: 308.452 °C at 760 mmHg
• Flash Point: 140.347 °C
• PSA: 29.54000
• Density: 1.564 g/cm³
• LogP: 0.17800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 206.98949
• Heavy Atom Count: 10
• Complexity: 123

Purity/Quality:

97% ^*data from raw suppliers

4-(Bromoacetyl)morpholine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(=O)CBr

Technology Process of 4-(Bromoacetyl)morpholine

There total 6 articles about 4-(Bromoacetyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 2-Bromoacetyl bromide (598-21-0) → N-(bromoacetyl)morpholine (40299-87-4)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.05.015

Reference yield: 66.0%

morpholine (110-91-8,99108-56-2) + 2-bromoacetyl chloride (22118-09-8) → N-(bromoacetyl)morpholine (40299-87-4)

Guidance literature:

With triethylamine; In chloroform; at -50 - -15 ℃;

DOI:10.1021/jm00384a003

Reference yield:

morpholine (110-91-8,99108-56-2) + bromoacetic acid (79-08-3) → N-(bromoacetyl)morpholine (40299-87-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 50 ℃;

DOI:10.1111/cbdd.12839

upstream raw materials:

morpholine

2-bromoacetyl chloride

2-Bromoacetyl bromide

bromoacetic anhydride

Downstream raw materials:

N-(2(R)-hydroxy-1(S)-indanyl)-5(S)-<(tert-butyloxycarbonyl)amino>-4(S)-hydroxy-6-phenyl-2(R)-<<4-<2-oxo-2-(4-morpholinyl)ethoxy>phenyl>methyl>hexanamide

4'-[1-Methyl-5-(2-morpholin-4-yl-2-oxo-ethoxy)-3-propyl-1H-pyrazol-4-ylmethyl]-biphenyl-2-carbonitrile

4'-[5-(2-Morpholin-4-yl-2-oxo-ethoxy)-3-propyl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-4-ylmethyl]-biphenyl-2-carbonitrile

1-Morpholin-4-yl-2-(2-nitro-benzenesulfonyl)-ethanone