CHEMBRDG-BB 4023671

Base Information

• Chemical Name: CHEMBRDG-BB 4023671
• CAS No.: 40299-87-4
• Molecular Formula: C6H10BrNO2
• Molecular Weight: 208.055
• Hs Code.: 2934999090
• Mol file: 40299-87-4.mol

Synonyms:CHEMBRDG-BB 4023671;4-(BROMOACETYL)MORPHOLINE;morpholine, 4-(bromoacetyl)-;4-(bromoacetyl)morpholine(SALTDATA: FREE);2-BroMo-1-(Morpholin-4-yl)ethanone;4-(2-BroMoacetyl)Morpholine;2-BroMo-1-(Morpholin-4-yl)ethan-1-one;2-Bromo-1-morpholinoethanone

Chemical Property of CHEMBRDG-BB 4023671

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.522
• Boiling Point: 308.452 °C at 760 mmHg
• Flash Point: 140.347 °C
• PSA: 29.54000
• Density: 1.564 g/cm³
• LogP: 0.17800
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-(Bromoacetyl)morpholine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CHEMBRDG-BB 4023671

There total 6 articles about CHEMBRDG-BB 4023671 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

morpholine (110-91-8,99108-56-2) + 2-Bromoacetyl bromide (598-21-0) → N-(bromoacetyl)morpholine (40299-87-4)

Guidance literature:

In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.1016/j.tetlet.2011.05.015

Reference yield: 66.0%

morpholine (110-91-8,99108-56-2) + 2-bromoacetyl chloride (22118-09-8) → N-(bromoacetyl)morpholine (40299-87-4)

Guidance literature:

With triethylamine; In chloroform; at -50 - -15 ℃;

DOI:10.1021/jm00384a003

Reference yield:

morpholine (110-91-8,99108-56-2) + bromoacetic acid (79-08-3) → N-(bromoacetyl)morpholine (40299-87-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 50 ℃;

DOI:10.1111/cbdd.12839

upstream raw materials:

morpholine

2-bromoacetyl chloride

2-Bromoacetyl bromide

bromoacetic anhydride

Downstream raw materials:

4'-[1-Methyl-5-(2-morpholin-4-yl-2-oxo-ethoxy)-3-propyl-1H-pyrazol-4-ylmethyl]-biphenyl-2-carbonitrile

4'-[5-(2-Morpholin-4-yl-2-oxo-ethoxy)-3-propyl-1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-4-ylmethyl]-biphenyl-2-carbonitrile

methyl 4-bromo-3-{[2-(4-morpholinyl)-2-oxoethyl]oxy}benzoate

C₂₇H₄₃N₃O₇

Refernces

• 1、 Verma, Kirti Dhingra,Forgacs, Attila,Uh, Hyounsoo,Beyerlein, Michael,Maier, Martin E.,Petoud, Stephane,Botta, Mauro,Logothetis, Nikos K.. "New calcium-selective smart contrast agents for magnetic resonance imaging". . p. 18011 - 18026. Retrieved 2013.
• 2、 Hussain, Javeena,Sahrawat, Parul,Dubey, Pankaj,Kirubakaran, Sivapriya,Thiruvenkatam, Vijay. "Exploring packing features of N-substituted acridone derivatives: Synthesis and X-ray crystallography studies". . . Retrieved 2021/09/20.
• 3、 Wu, Wenxi,Mu, Yu,Liu, Bo,Wang, Zixuan,Guan, Peipei,Han, Li,Jiang, Mingguo,Huang, Xueshi. "Biomimetic synthesis and anti-inflammatory evaluation of violacin A analogues". . . Retrieved 2021/04/23.