Ethyl 5-amino-2-methylthiazole-4-carboxylate

Base Information

Chemical Name:Ethyl 5-amino-2-methylthiazole-4-carboxylate
CAS No.:31785-05-4
Molecular Formula:C7H10N2O2S
Molecular Weight:186.235
Hs Code.:2934100090
European Community (EC) Number:801-994-6
DSSTox Substance ID:DTXSID20536992
Nikkaji Number:J344.470H
Wikidata:Q82411830
Mol file:31785-05-4.mol

Synonyms:31785-05-4;ETHYL 5-AMINO-2-METHYLTHIAZOLE-4-CARBOXYLATE;ethyl 5-amino-2-methyl-1,3-thiazole-4-carboxylate;5-AMINO-2-METHYL-THIAZOLE-4-CARBOXYLIC ACID ETHYL ESTER;5-Amino-2-methylthiazole-4-carboxylic acid ethyl ester;MFCD07357418;4-Thiazolecarboxylic acid, 5-amino-2-methyl-, ethyl ester;SCHEMBL1194383;HNDBOQZBZYRXMF-UHFFFAOYSA-;DTXSID20536992;HNDBOQZBZYRXMF-UHFFFAOYSA-N;AMY11593;AKOS006284799;AB30639;CS-W016895;DS-17644;SY065513;EN300-99873;ethyl 5-amino-2-methyl-thiazole-4-carboxylate;A807414;ethyl 5-azanyl-2-methyl-1,3-thiazole-4-carboxylate;ETHYL5-AMINO-2-METHYLTHIAZOLE-4-CARBOXYLATE;J-521099;5-amino-2-methyl-4-thiazolecarboxylic acid ethyl ester;5-Amino-2-methylthiazole-4-carboxylic acid ethyl ester, AldrichCPR;InChI=1/C7H10N2O2S/c1-3-11-7(10)5-6(8)12-4(2)9-5/h3,8H2,1-2H3

Suppliers and Price of Ethyl 5-amino-2-methylthiazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl5-amino-2-methylthiazole-4-carboxylate
50mg
$ 55.00

SynQuest Laboratories
Ethyl 5-amino-2-methyl-1,3-thiazole-4-carboxylate
1 g
$ 397.00

Sigma-Aldrich
5-Amino-2-methylthiazole-4-carboxylic acid ethyl ester AldrichCPR
1g
$ 315.00

Matrix Scientific
5-Amino-2-methylthiazole-4-carboxylic acid ethyl ester 97%
500mg
$ 155.00

Matrix Scientific
5-Amino-2-methylthiazole-4-carboxylic acid ethyl ester 97%
1g
$ 240.00

Matrix Scientific
5-Amino-2-methylthiazole-4-carboxylic acid ethyl ester 97%
5g
$ 720.00

Crysdot
Ethyl5-amino-2-methylthiazole-4-carboxylate 98%
10g
$ 514.00

Crysdot
Ethyl5-amino-2-methylthiazole-4-carboxylate 98%
5g
$ 302.00

Chemenu
ethyl5-amino-2-methylthiazole-4-carboxylate 98%
1g
$ 161.00

Chemenu
ethyl5-amino-2-methylthiazole-4-carboxylate 98%
10g
$ 888.00

Total 33 raw suppliers

Chemical Property of Ethyl 5-amino-2-methylthiazole-4-carboxylate

Chemical Property:

Vapor Pressure:0.001mmHg at 25°C
Melting Point:158-159 °C
Refractive Index:1.579
Boiling Point:301.941 °C at 760 mmHg
PKA:2.38±0.10(Predicted)
Flash Point:136.409 °C
PSA：93.45000
Density:1.284 g/cm³
LogP:1.79160
Storage Temp.:2-8°C(protect from light)
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:186.04629874
Heavy Atom Count:12
Complexity:177

Purity/Quality:

99%, ^*data from raw suppliers

Ethyl5-amino-2-methylthiazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(SC(=N1)C)N

Technology Process of Ethyl 5-amino-2-methylthiazole-4-carboxylate

There total 2 articles about Ethyl 5-amino-2-methylthiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 3356-83-0
2-methyl-4-(methylaminocarbonyl)-5-ethoxyoxazole

: 128269-81-8
2-methyl-4-<(N-methylamino)thiocarbonyl>-5-ethoxyoxazole

: 31785-05-4
5-amino-2-methyl-1,3-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: With Lawessons reagent; In tetrahydrofuran; for 2h; Heating;
DOI:10.1021/jo00301a056

Reference yield:

: 6436-59-5
ethyl 2-methylthiazole-4-carboxylate

: 31785-05-4
5-amino-2-methyl-1,3-thiazole-4-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide / acetonitrile / 48 h / 40 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / toluene / 20.17 h / 80 °C / Inert atmosphere

3: hydrogenchloride / tetrahydrofuran / 4 h / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; N-Bromosuccinimide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; toluene; acetonitrile;

Reference yield: 83.0%

: 6-chloro-N-cyclopropyl-8-((4-methoxybenzyl)(methyl)amino)imidazo[1,2-b]pyridazine-3-carboxamide

: 31785-05-4
5-amino-2-methyl-1,3-thiazole-4-carboxylic acid ethyl ester

: ethyl 5-((3-(cyclopropylcarbamoyl)-8-((4-methoxybenzyl)(methyl)amino)imidazo[1,2-b]pyridazin-6-yl)amino)-2-methylthiazole-4-carboxylate

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dicyclohexyl-(2′,4′,6′-triisopropyl-3,6-dimethoxy-[1,1′-biphenyl]-2-yl)phosphine; caesium carbonate; In N,N-dimethyl acetamide; at 115 ℃; Inert atmosphere;