6-t-butylpyridine-3-carboxamide

Base Information

• Chemical Name: 6-t-butylpyridine-3-carboxamide
• CAS No.: 4138-22-1
• Molecular Formula: C₁₀H₁₄N₂O
• Molecular Weight: 178.234
• Mol file: 4138-22-1.mol

Synonyms:

Chemical Property of 6-t-butylpyridine-3-carboxamide

Chemical Property:

• Melting Point: 178 °C
• Boiling Point: 304.7±30.0 °C(Predicted)
• PKA: 15.08±0.50(Predicted)
• Density: 1.060±0.06 g/cm3(Predicted)

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-t-butylpyridine-3-carboxamide

There total 4 articles about 6-t-butylpyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

nicotinamide (98-92-0,1255150-40-3) + Trimethylacetic acid (75-98-9) → 6-t-butylpyridine-3-carboxamide (4138-22-1)

Guidance literature:

With ammonium persulfate; sulfuric acid; silver nitrate; In water; at 70 ℃; for 2h;

Reference yield: 67.0%

potassium tert-butyltrifluoroboranuide + nicotinamide (98-92-0,1255150-40-3) → 6-t-butylpyridine-3-carboxamide (4138-22-1)

Guidance literature:

With dipotassium peroxodisulfate; trifluoroacetic acid; 9-mesityl-10-methylacridinium ion; In water; acetonitrile; at 23 ℃; for 4h; regioselective reaction; Irradiation;

DOI:10.1039/c7sc00283a

Reference yield: 40.0%

S-tert-butyl O-ethyl carbonodithioate (84380-38-1) + nicotinamide (98-92-0,1255150-40-3) → 6-t-butylpyridine-3-carboxamide (4138-22-1)

Guidance literature:

With dilauryl peroxide; camphor-10-sulfonic acid; In 1,2-dichloro-ethane; at 85 ℃; for 1h; Sealed tube;

DOI:10.1021/acs.orglett.8b01299

upstream raw materials:

nicotinamide

Trimethylacetic acid

S-tert-butyl O-ethyl carbonodithioate

Refernces

• 1、 Matsui, Jennifer K.,Primer, David N.,Molander, Gary A.. "Metal-free C-H alkylation of heteroarenes with alkyltrifluoroborates: A general protocol for 1°, 2° and 3° alkylation". . p. 3512 - 3522. Retrieved 2017/07/10.