BETA-OXO-1-BOC-4-PIPERIDINEBUTANOIC ACID METHYL ESTER

Base Information

• Chemical Name: BETA-OXO-1-BOC-4-PIPERIDINEBUTANOIC ACID METHYL ESTER
• CAS No.: 1014679-82-3
• Molecular Formula: C₁₅H₂₅NO₅
• Molecular Weight: 299.367
• Mol file: 1014679-82-3.mol

Synonyms:

Chemical Property of BETA-OXO-1-BOC-4-PIPERIDINEBUTANOIC ACID METHYL ESTER

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Methylb-oxo-1-Boc-4-piperidinebutanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BETA-OXO-1-BOC-4-PIPERIDINEBUTANOIC ACID METHYL ESTER

There total 2 articles about BETA-OXO-1-BOC-4-PIPERIDINEBUTANOIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C15H23N3O3 + potassium methyl malonate (1149755-00-9) → 4-(3-methoxycarbonyl-2-oxo-propyl)piperidine-1-carboxylic acid tert-butyl ester (1014679-82-3)

Guidance literature:

potassium methyl malonate; With magnesium chloride; In tetrahydrofuran; at 50 ℃; for 5h;

C₁₅H₂₃N₃O₃; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

C15H23N3O3 + monomethyl monopotassium malonate (38330-80-2) → 4-(3-methoxycarbonyl-2-oxo-propyl)piperidine-1-carboxylic acid tert-butyl ester (1014679-82-3)

Guidance literature:

monomethyl monopotassium malonate; With magnesium chloride; In tetrahydrofuran; at 50 ℃; for 5h;

C₁₅H₂₃N₃O₃; In tetrahydrofuran; at 20 ℃; for 12h; Further stages.;

DOI:10.1021/jo702551t

upstream raw materials:

monomethyl monopotassium malonate

potassium methyl malonate

Refernces

• 1、 -. "Enantioselective process for preparing a substituted alkanoic acid". Page/Page column 56. . Retrieved 2009/05/28.