2-(2-Chloro-5-iodine benzyl)-5-(3-(6-fluoro-pyridyl)) thiophene

Base Information

• Chemical Name: 2-(2-Chloro-5-iodine benzyl)-5-(3-(6-fluoro-pyridyl)) thiophene
• CAS No.: 1131770-46-1
• Molecular Formula: C16H10ClFINS
• Molecular Weight: 429.684
• Mol file: 1131770-46-1.mol

Synonyms:5-(5-(2-Chloro-5-iodobenzyl)thiophen-2-yl)-2-fluoropyridine;5-[5-[(2-chloro-5-iodophenyl)methyl]thiophen-2-yl]-2-fluoropyridine;2-(2-Chloro-5-iodinebenzyl)-5-(3-(6-fluoropyridyl))thiophene;

Chemical Property of 2-(2-Chloro-5-iodine benzyl)-5-(3-(6-fluoro-pyridyl)) thiophene

Chemical Property:

• Boiling Point: 482.879 °C at 760 mmHg
• Flash Point: 245.837 °C
• PSA: 41.13000
• Density: 1.685 g/cm³
• LogP: 5.79800
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

5-(5-(2-Chloro-5-iodobenzyl)thiophen-2-yl)-2-fluoropyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Chloro-5-iodine benzyl)-5-(3-(6-fluoro-pyridyl)) thiophene

There total 1 articles about 2-(2-Chloro-5-iodine benzyl)-5-(3-(6-fluoro-pyridyl)) thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-chloro-5-iodo-phenyl)-[5-(6-fluoro-pyridin-3-yl)-thiophen-2-yl]-methanone (1132832-77-9) → 5-[5-(2-chloro-5-iodo-benzyl)-thiophen-2-yl]-2-fluoro-pyridine (1131770-46-1)

Guidance literature:

(2-chloro-5-iodo-phenyl)-[5-(6-fluoro-pyridin-3-yl)-thiophen-2-yl]-methanone; With triethylsilane; boron trifluoride diethyl etherate; In acetonitrile; at 20 - 58 ℃;

With water; sodium hydrogencarbonate; In acetonitrile; at 5 - 20 ℃; for 1h;

Reference yield:

5-[5-(2-chloro-5-iodo-benzyl)-thiophen-2-yl]-2-fluoro-pyridine (1131770-46-1) + (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one (32469-28-6,55515-28-1,55515-29-2,32384-65-9) → C34H53ClFNO6SSi4 (1132832-78-0)

Guidance literature:

5-[5-(2-chloro-5-iodo-benzyl)-thiophen-2-yl]-2-fluoro-pyridine; (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; With trimethylsilylmethyllithium; In tetrahydrofuran; hexanes; at -70 - -60 ℃; Molecular sieve;

With water; sodium hydrogencarbonate; In tetrahydrofuran; hexanes; at -30 ℃;

Reference yield:

5-[5-(2-chloro-5-iodo-benzyl)-thiophen-2-yl]-2-fluoro-pyridine (1131770-46-1) + (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one (32469-28-6,55515-28-1,55515-29-2,32384-65-9) → C22H21ClFNO6S (1132832-79-1)

Guidance literature:

5-[5-(2-chloro-5-iodo-benzyl)-thiophen-2-yl]-2-fluoro-pyridine; (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one; With trimethylsilylmethyllithium; In tetrahydrofuran; at -70 ℃; for 0.333333h;

With hydrogenchloride; In tetrahydrofuran; water; at -70 ℃;

upstream raw materials:

(2-chloro-5-iodo-phenyl)-[5-(6-fluoro-pyridin-3-yl)-thiophen-2-yl]-methanone

Downstream raw materials:

C₃₄H₅₃ClFNO₆SSi₄

C₂₂H₂₁ClFNO₆S

(2S,3R,4R,5S,6R)-2-[3-((5-(6-fluoropyridin-3-yl)thien-2-yl)-methyl)-4-chlorophenyl]-6-methylthiotetrahydropyran-3,4,5-triol

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