4-Bromo-7-methoxy-2-(trifluoromethyl)quinoline

Base Information

Chemical Name:4-Bromo-7-methoxy-2-(trifluoromethyl)quinoline
CAS No.:89446-63-9
Molecular Formula:C₁₁H₇BrF₃NO
Molecular Weight:306.082
Hs Code.:
DSSTox Substance ID:DTXSID90448573
Wikidata:Q82267627
Mol file:89446-63-9.mol

Synonyms:4-bromo-7-methoxy-2-(trifluoromethyl)quinoline;89446-63-9;SCHEMBL9830225;DTXSID90448573;OYWLVNNZFBCMPN-UHFFFAOYSA-N;AKOS023114800

Suppliers and Price of 4-Bromo-7-methoxy-2-(trifluoromethyl)quinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 4-Bromo-7-methoxy-2-(trifluoromethyl)quinoline

Chemical Property:

PSA：22.12000
LogP:4.02470
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:1
Exact Mass:304.96631
Heavy Atom Count:17
Complexity:274

Purity/Quality:: 99%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=C1)C(=CC(=N2)C(F)(F)F)Br

Technology Process of 4-Bromo-7-methoxy-2-(trifluoromethyl)quinoline

There total 3 articles about 4-Bromo-7-methoxy-2-(trifluoromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 39975-59-2
7-methoxy-2-trifluoromethyl-4(1H)-quinolinone

: 89446-63-9
4-bromo-7-methoxy-2-(trifluoromethyl)quinoline

Guidance literature:: With phosphorus(V) oxybromide; at 150 ℃; for 2h;
DOI:10.1002/ejoc.200390217

Reference yield: 3.0%

: 41192-85-2
7-methoxy-2-trifluoromethyl-1H-quinolin-4-one

: 89446-64-0
4,8-dibromo-7-methoxy-2-trifluoromethylquinoline

: 89446-63-9
4-bromo-7-methoxy-2-(trifluoromethyl)quinoline

Guidance literature:: With phosphorus(V) oxybromide;

Reference yield:

: 536-90-3,918666-97-4
m-Anisidine

: 89446-63-9
4-bromo-7-methoxy-2-(trifluoromethyl)quinoline

Guidance literature:: Multi-step reaction with 2 steps

1: 32 percent / polyphosphoric acid / 2 h / 150 °C

2: 71 percent / phosphorus oxybromide / 2 h / 150 °C

With PPA; phosphorus(V) oxybromide;
DOI:10.1002/ejoc.200390217