(5-chlorothiophen-2-yl)methanamine hydrochloride

Base Information

• Chemical Name: (5-chlorothiophen-2-yl)methanamine hydrochloride
• CAS No.: 548772-41-4
• Molecular Formula: C5H7Cl2NS
• Molecular Weight: 184
• Hs Code.: 2934999090
• Mol file: 548772-41-4.mol

Synonyms:HT757;C-(5-chloro-[2]thienyl)-methylamine,hydrochloride;(5-chlorothiophen-2-yl)methanamine hydrochloride;C-(5-Chlor-[2]thienyl)-methylamin,Hydrochlorid;(5-chlorothien-2-yl)methylamine hydrochloride;(5-chlorothiophen-2-yl)methylamine hydrochloride;

Chemical Property of (5-chlorothiophen-2-yl)methanamine hydrochloride

Chemical Property:

• Melting Point: 280-282 °C (decomp)
• PSA: 54.26000
• LogP: 3.36250
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

(5-chlorothiophen-2-yl)methanaminehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (5-chlorothiophen-2-yl)methanamine hydrochloride

There total 1 articles about (5-chlorothiophen-2-yl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2-Aminomethylthiophene (27757-85-3) → (5-chlorothiophen-2-yl)methylamine hydrochloride (548772-41-4)

Guidance literature:

With sulfuryl dichloride; acetic acid; In diethyl ether; at 20 ℃;

DOI:10.1055/s-2003-37362

Reference yield:

4-((diphenylmethyleneamino)methyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxylic acid (1035346-03-2) + (5-chlorothiophen-2-yl)methylamine hydrochloride (548772-41-4) → N-((5-chlorothiophen-2-yl)methyl)-4-((diphenylmethyleneamino)methyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (1035346-68-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In ISOPROPYLAMIDE; at 20 ℃; for 24h;

upstream raw materials:

2-Aminomethylthiophene

Downstream raw materials:

N-((5-chlorothiophen-2-yl)methyl)-4-((diphenylmethyleneamino)methyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide