4,7-Dichloro benzothiophene

Base Information

• Chemical Name: 4,7-Dichloro benzothiophene
• CAS No.: 318463-07-9
• Molecular Formula: C8H4Cl2S
• Molecular Weight: 203.09
• Mol file: 318463-07-9.mol

Synonyms:4,7-dichloro-1-benzothiophene

Chemical Property of 4,7-Dichloro benzothiophene

Chemical Property:

• Vapor Pressure: 0.0028mmHg at 25°C
• Refractive Index: 1.688
• Boiling Point: 294.8 °C at 760 mmHg
• Flash Point: 174.7 °C
• PSA: 28.24000
• Density: 1.483 g/cm³
• LogP: 4.20810
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4,7-Dichlorobenzo[b]thiophene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,7-Dichloro benzothiophene

There total 2 articles about 4,7-Dichloro benzothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(1-adamantylsulfanyl)-3,6-dichlorobenzaldehyde + dimethyl 1-(1-diazo-2-oxopropyl)phosphonate (90965-06-3) → C8H4Cl2S (318463-07-9) + 2-(1-adamantylsulfanyl)-1,4-dichloro-3-ethynylbenzene

Guidance literature:

With potassium carbonate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 19.3333h;

DOI:10.3987/COM-19-14132

Reference yield:

3,6-dichloro-2-fluorobenzaldehyde (916420-61-6) → C8H4Cl2S (318463-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1.5 h / 0 °C / Inert atmosphere

1.2: 2 h / -40 °C / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran; methanol / 19.33 h / 0 - 20 °C

With sodium hydride; potassium carbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;

DOI:10.3987/COM-19-14132

upstream raw materials:

dimethyl 1-(1-diazo-2-oxopropyl)phosphonate

3,6-dichloro-2-fluorobenzaldehyde

Refernces