4-Ethylphenylmagnesium bromide

Base Information

• Chemical Name: 4-Ethylphenylmagnesium bromide
• CAS No.: 22873-28-5
• Molecular Formula: C8H9BrMg
• Molecular Weight: 209.368
• Hs Code.: 29319090
• Mol file: 22873-28-5.mol

Synonyms:4-ETHYLPHENYLMAGNESIUM BROMIDE;4-ETHYLPHENYLMAGNESIUM BROMIDE, 0.5M SOLUT TION IN TETRAHYDROFURAN;4-ethylphenylmagnesium bromide solution;4-Ethylphenylmagnesium bromide solution 0.5 in THF;4-Ethylphenylmagnesium bromide, 0.5M solution in THF, AcroSeal;4-EthylphenylMagnesiuM broMide, 0.5M in 2-MeTHF;4-Ethylphenylmagnesium bromide 1M solution in THF;4-EthylphenylMagnesiuM broMide, 0.5M solution in THF, J&KSeal

Chemical Property of 4-Ethylphenylmagnesium bromide

Chemical Property:

• Vapor Pressure: 9.21mmHg at 25°C
• Boiling Point: 65 °C
• Flash Point: 1 °F
• PSA: 0.00000
• Density: 0.950 g/mL at 25 °C
• LogP: -0.74400
• Storage Temp.: 2-8°C
• Sensitive.: Air & Moisture Sensitive
• Water Solubility.: Reacts with water.

Purity/Quality:

99% ^*data from raw suppliers

4-Ethylphenylmagnesium bromide solution 0.5M in THF ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F;C
• Hazard Codes: F,C,Xn
• Statements: 11-14/15-19-34-40-36/37-14
• Safety Statements: 16-26-33-36/37/39-43-45-36/37-8

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Ethylphenylmagnesium bromide, 0.5M in 2-MeTHF is used as a pharmaceutical intermediate.

Technology Process of 4-Ethylphenylmagnesium bromide

There total 4 articles about 4-Ethylphenylmagnesium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-ethylbenzene (1585-07-5) → p-ethylphenylmagnesium bromide (22873-28-5)

Guidance literature:

With magnesium; In tetrahydrofuran;

Reference yield:

1 N-HCl + 4-(1-methyl-1,2,3,4-tetrazol-5-yl)thiobutyronitrile (80086-16-4) + 1-bromo-4-ethylbenzene (1585-07-5) → p-ethylphenylmagnesium bromide (22873-28-5) + 1-methyl-5-[3-(4-ethylbenzoyl)propyl]thio-1,2,3,4-tetrazole (80087-35-0)

Guidance literature:

With magnesium; In tetrahydrofuran;

Reference yield:

bromobenzene (108-86-1,52753-63-6) → p-ethylphenylmagnesium bromide (22873-28-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 60 percent / anhydrous aluminium chloride / 2 h / 70 °C

2: 75 percent / hydrazine hydrate, potassium hydroxide / bis-(2-hydroxy-ethyl) ether / 6 h / 130 - 180 °C

3: magnesium turnings / tetrahydrofuran

With potassium hydroxide; aluminium trichloride; hydrazine hydrate; magnesium; In tetrahydrofuran; diethylene glycol;

upstream raw materials:

1-bromo-4-ethylbenzene

bromobenzene

para-bromoacetophenone

4-(1-methyl-1,2,3,4-tetrazol-5-yl)thiobutyronitrile

Downstream raw materials:

2-Chlor-4'-ethyl-diphenylmethan

2-(4-ethylphenyl)-4,4-dimethyl-2-oxazoline

Dichlor-methyl-<4-ethyl-phenyl>-silan

7-(4-ethylphenyl)tropylidene

Refernces

• 1、 Chan, L. K. M.,Gray, G. W.,Lacey, D.,Toyne, K. J.. "Synthesis and Liquid Crystal Behaviour of Further 4,4"-Disubstituted 2'-Fluoro-1,1':4',1"-Terphenyls". . p. 209 - 240. Retrieved 2007/10/02.