Technology Process of (-)-(7R,14R)-7-Benzyloxy-14--1-(2,4,10-trioxatricyclo<3.3.1.13,7>dec-3-yl)pentadecan
There total 19 articles about (-)-(7R,14R)-7-Benzyloxy-14--1-(2,4,10-trioxatricyclo<3.3.1.13,7>dec-3-yl)pentadecan which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88 percent / pyridine / 2 h / 4 °C
2: 100 percent / LiBr / tetrahydrofuran / 1 h / Ambient temperature
3: 1) Mg, 1,2-dibromoethane / 2) 1,5-cyclooctadiene-CuCl / 1) THF, 1 h, reflux 2) 30 min
4: 1) NaH / 1) THF, 30 min 2) 14 h, reflux
With
pyridine; sodium hydride; magnesium; ethylene dibromide; lithium bromide;
2) 1,5-cyclooctadiene-CuCl;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 88 percent / pyridine / 2 h / 4 °C
2: 100 percent / LiBr / tetrahydrofuran / 1 h / Ambient temperature
3: 1) Mg, 1,2-dibromoethane / 2) 1,5-cyclooctadiene-CuCl / 1) THF, 1 h, reflux 2) 30 min
4: 1) NaH / 1) THF, 30 min 2) 14 h, reflux
With
pyridine; sodium hydride; magnesium; ethylene dibromide; lithium bromide;
2) 1,5-cyclooctadiene-CuCl;
In
tetrahydrofuran;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 65 percent / imidazol / dimethylformamide / 16 h
2: 92 percent / H2, AcOH / 10percent Pd/C / methanol / 0.67 h
3: 88 percent / pyridine / 2 h / 4 °C
4: 100 percent / LiBr / tetrahydrofuran / 1 h / Ambient temperature
5: 1) Mg, 1,2-dibromoethane / 2) 1,5-cyclooctadiene-CuCl / 1) THF, 1 h, reflux 2) 30 min
6: 1) NaH / 1) THF, 30 min 2) 14 h, reflux
With
pyridine; 1H-imidazole; hydrogen; sodium hydride; magnesium; acetic acid; ethylene dibromide; lithium bromide;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;