6-bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine

Base Information

Chemical Name:6-bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine
CAS No.:2226517-76-4
Molecular Formula:C₁₈H₁₇BrN₂O₃
Molecular Weight:389.249
Hs Code.:2933499090

Synonyms:

Suppliers and Price of 6-bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SGCGAK1
1mg
$ 75.00

Tocris
SGCGAK1 ≥99%(HPLC)
25
$ 311.00

Tocris
SGCGAK1 ≥99%(HPLC)
5
$ 80.00

Sigma-Aldrich
SGC-GAK-1 ≥98% (HPLC)
5mg
$ 87.50

Sigma-Aldrich
SGC-GAK-1 ≥98% (HPLC)
25mg
$ 355.00

DC Chemicals
SGC-GAK-1 >98%
250 mg
$ 1350.00

DC Chemicals
SGC-GAK-1 >98%
1 g
$ 2700.00

DC Chemicals
SGC-GAK-1 >98%
100 mg
$ 800.00

Biosynth Carbosynth
SGC GAK 1 NEW
10 mg
$ 75.00

Biosynth Carbosynth
SGC GAK 1 NEW
50 mg
$ 262.50

Total 14 raw suppliers

Chemical Property of 6-bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine

Chemical Property:

Boiling Point:484.9±45.0 °C(Predicted)
Density:1.436±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

SGCGAK1 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description SGC-GAK-1 (2226517-76-4) is a highly potent and selective inhibitor of cyclin G associated kinase (GAK), a member of the numb-associated kinase (NAK) family involved in membrane trafficking and sorting of proteins and is required for the maintenance of centrosome maturation and progression though mitosis. KD?= 1.9 nM with >50-fold selectivity against a panel of 400 kinases. It also displayed affinity for RIPK2 (KD?= 110 nM) and ADCK3 (KD?= 190 nM). SGC-GAK-1 displayed potent cellular activity in HEK293T cells (IC50?= 120 nM) and showed strong growth inhibition in the prostate cancer cell lines LNCaP (IC50?= 0.65 μM) and 22Rv1 (IC50?= 0.17 μM).
Uses SGC GAK 1 is a high affinity cyclin G associated kinase (GAK) inhibitor (Kd = 1.9 nM). Exhibited >30-fold selectivity for GAK versus a panel of other kinases. Inhibits GAK in live cell assays (IC50 = 110 nM).

Technology Process of 6-bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine

There total 1 articles about 6-bromo-N-(3,4,5-trimethoxyphenyl)quinolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%