C₂₄H₂₂ClF₃N₂O₃

Base Information

• Chemical Name: C₂₄H₂₂ClF₃N₂O₃
• CAS No.: 1334392-87-8
• Molecular Formula: C₂₄H₂₂ClF₃N₂O₃
• Molecular Weight: 478.898
• Mol file: 1334392-87-8.mol

Synonyms:

Chemical Property of C₂₄H₂₂ClF₃N₂O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₂ClF₃N₂O₃

There total 12 articles about C₂₄H₂₂ClF₃N₂O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-4-[4-(trifluoromethoxy)phenoxy]benzene (873203-36-2) → C24H22ClF3N2O3 (1334392-87-8)

Guidance literature:

Multi-step reaction with 7 steps

1: n-butyllithium / tetrahydrofuran / -78 °C

2: hydrogenchloride / water / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

4: ammonia / ethanol; water / 140 °C

5: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C

6: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

7: sodium tris(acetoxy)borohydride; acetic acid / DCE / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; trichloroisocyanuric acid; ammonia; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; DCE; ethanol; dichloromethane; water; toluene; 3: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one (501-30-4,123712-78-7) → C24H22ClF3N2O3 (1334392-87-8)

Guidance literature:

Multi-step reaction with 8 steps

1: sodium hydroxide / water / 20 °C

2: hydrogenchloride; zinc / water / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

5: ammonia / ethanol; water / 140 °C

6: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C

7: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

8: sodium tris(acetoxy)borohydride; acetic acid / DCE / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; trichloroisocyanuric acid; ammonia; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium carbonate; potassium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; sodium hydroxide; zinc; In methanol; DCE; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 4: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.07.044

Reference yield:

(4-(4-(trifluoromethoxy)phenoxy)phenyl)boronic acid (958457-41-5) → C24H22ClF3N2O3 (1334392-87-8)

Guidance literature:

Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / ethanol; water; toluene / 80 °C

2: ammonia / ethanol; water / 140 °C

3: trichloroisocyanuric acid / methanol; dichloromethane / 0 - 20 °C

4: sulfur trioxide pyridine complex; dimethyl sulfoxide; triethylamine / dichloromethane / 0 - 20 °C

5: sodium tris(acetoxy)borohydride; acetic acid / DCE / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; trichloroisocyanuric acid; ammonia; sulfur trioxide pyridine complex; sodium tris(acetoxy)borohydride; sodium carbonate; acetic acid; dimethyl sulfoxide; triethylamine; In methanol; DCE; ethanol; dichloromethane; water; toluene; 1: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.07.044

upstream raw materials:

1-bromo-4-[4-(trifluoromethoxy)phenoxy]benzene

(4-(4-(trifluoromethoxy)phenoxy)phenyl)boronic acid

5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one

3-hydroxy-6-hydroxymethyl-2-methyl-pyran-4-one