C₂₁H₂₃F₃N₄O₂

Base Information

• Chemical Name: C₂₁H₂₃F₃N₄O₂
• CAS No.: 1366126-40-0
• Molecular Formula: C₂₁H₂₃F₃N₄O₂
• Molecular Weight: 420.434
• Mol file: 1366126-40-0.mol

Synonyms:

Chemical Property of C₂₁H₂₃F₃N₄O₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₃F₃N₄O₂

There total 4 articles about C₂₁H₂₃F₃N₄O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C8H8ClN3O (1366126-67-1) → C21H23F3N4O2 (1366126-40-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2: 150 °C / Microwave irradiation

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.01.092

Reference yield:

4,5-dimethyl-1H-imidazol-2-amine (13805-21-5) → C21H23F3N4O2 (1366126-40-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium ethanolate / ethanol / Reflux

2: trichlorophosphate / 80 °C

3: sodium hydroxide / 100 °C

4: potassium carbonate / N,N-dimethyl-formamide / 20 °C

5: 150 °C / Microwave irradiation

With sodium ethanolate; potassium carbonate; sodium hydroxide; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.01.092

Reference yield:

C8H7Cl2N3 (1366126-63-7) → C21H23F3N4O2 (1366126-40-0)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: 150 °C / Microwave irradiation

With potassium carbonate; sodium hydroxide; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2012.01.092

upstream raw materials:

morpholine

C₁₇H₁₅ClF₃N₃O

4,5-dimethyl-1H-imidazol-2-amine

C₈H₇Cl₂N₃