2-amino-5-ethyl-2',4'-difluorobenzophenone

Base Information

• Chemical Name: 2-amino-5-ethyl-2',4'-difluorobenzophenone
• CAS No.: 119983-22-1
• Molecular Formula: C₁₅H₁₃F₂NO
• Molecular Weight: 261.271
• Mol file: 119983-22-1.mol

Synonyms:

Chemical Property of 2-amino-5-ethyl-2',4'-difluorobenzophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-5-ethyl-2',4'-difluorobenzophenone

There total 1 articles about 2-amino-5-ethyl-2',4'-difluorobenzophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

2,4-difluorobenzoyl chloride (72482-64-5) + 4-aminoethylbenzene (589-16-2) → 2-amino-5-ethyl-2',4'-difluorobenzophenone (119983-22-1)

Guidance literature:

With zinc(II) chloride; at 200 ℃; for 2.5h;

DOI:10.1248/cpb.41.894

Reference yield: 82.0%

acetic anhydride (108-24-7) + 2-amino-5-ethyl-2',4'-difluorobenzophenone (119983-22-1) → 2-(2,4-difluorobenzoyl)-4-ethylacetanilide (119983-25-4)

Guidance literature:

With pyridine; Ambient temperature;

DOI:10.1248/cpb.41.894

Reference yield:

2-amino-5-ethyl-2',4'-difluorobenzophenone (119983-22-1) → 1-[4-Amino-3-(2,4-difluoro-benzoyl)-phenyl]-ethanone (119983-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / pyridine / Ambient temperature

2: 71 percent / HNO₃, KMnO₄, MgO / H₂O / 9 h / 60 °C

3: 3.6 g / conc. HCl / ethanol / 5 h / Heating

With pyridine; hydrogenchloride; potassium permanganate; nitric acid; magnesium oxide; In ethanol; water;

DOI:10.1248/cpb.41.894

upstream raw materials:

2,4-difluorobenzoyl chloride

4-aminoethylbenzene

Downstream raw materials:

2-(2,4-difluorobenzoyl)-4-ethylacetanilide

1-[4-Amino-3-(2,4-difluoro-benzoyl)-phenyl]-ethanone

4-acetyl-2-(2,4-difluorobenzoyl)acetanilide