Ethyl 4-methyl-2-morpholinopyrimidine-5-carboxylate

Base Information

Chemical Name:Ethyl 4-methyl-2-morpholinopyrimidine-5-carboxylate
CAS No.:78318-44-2
Molecular Formula:C₁₂H₁₇N₃O₃
Molecular Weight:251.285
Hs Code.:2934999090
DSSTox Substance ID:DTXSID10506083
Wikidata:Q82361655
Mol file:78318-44-2.mol

Synonyms:78318-44-2;ETHYL 4-METHYL-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE;ethyl 4-methyl-2-morpholin-4-ylpyrimidine-5-carboxylate;ethyl 4-methyl-2-(morpholin-4-yl)pyrimidine-5-carboxylate;ethyl4-methyl-2-morpholinopyrimidine-5-carboxylate;DTXSID10506083;RXGOAHHHDBIXSA-UHFFFAOYSA-N;5-Pyrimidinecarboxylic acid, 4-methyl-2-(4-morpholinyl)-, ethyl ester;MFCD08131933;AKOS000605319;LS-05572;CS-0208352;A865053;ETHYL 4-METHYL-2-MORPHOLINO-5-PYRIMIDINECARBOXYLATE

Suppliers and Price of Ethyl 4-methyl-2-morpholinopyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ethyl4-methyl-2-morpholinopyrimidine-5-carboxylate
1g
$ 115.00

Matrix Scientific
Ethyl 4-methyl-2-morpholin-4-ylpyrimidine-5-carboxylate
500mg
$ 158.00

Crysdot
Ethyl4-methyl-2-morpholinopyrimidine-5-carboxylate 95+%
10g
$ 395.00

Chemenu
Ethyl4-methyl-2-morpholin-4-ylpyrimidine-5-carboxylate 95%
10g
$ 373.00

American Custom Chemicals Corporation
ETHYL-4-METHYL-2-MORPHOLINOPYRIMIDINE-5-CARBOXYLATE 95.00%
5MG
$ 498.44

AK Scientific
Ethyl4-methyl-2-morpholinopyrimidine-5-carboxylate
10g
$ 611.00

Total 10 raw suppliers

Chemical Property of Ethyl 4-methyl-2-morpholinopyrimidine-5-carboxylate

Chemical Property:

PSA：64.55000
LogP:0.86330
Storage Temp.:2-8°C
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:251.12699141
Heavy Atom Count:18
Complexity:282

Purity/Quality:

97% ^*data from raw suppliers

Ethyl4-methyl-2-morpholinopyrimidine-5-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CN=C(N=C1C)N2CCOCC2

Technology Process of Ethyl 4-methyl-2-morpholinopyrimidine-5-carboxylate

There total 3 articles about Ethyl 4-methyl-2-morpholinopyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 5638-78-8
morpholinoformamidine hydrochloride

: 3788-94-1
2-ethoxymethylene-3-oxobutanoic acid ethyl ester

: 78318-44-2
4-Methyl-2-morpholino-pyrimidin-5-carbonsaeure-ethylester

Guidance literature:: With sodium ethanolate; In ethanol; 30 min, room temp.; 24 h, 4 deg C;

Reference yield:

: 134653-70-6,51145-57-4
ethyl 2-[(dimethylamino)methylene]-3-oxobutanoate

: 157415-17-3
Morpholine-4-carboxamidine; hydrobromide

: 78318-44-2
4-Methyl-2-morpholino-pyrimidin-5-carbonsaeure-ethylester

Guidance literature:: With sodium methylate; In methanol; at 80 ℃; for 6h;
DOI:10.1016/j.bmcl.2012.08.070

Reference yield:

: 141-97-9
ethyl acetoacetate

: 78318-44-2
4-Methyl-2-morpholino-pyrimidin-5-carbonsaeure-ethylester

Guidance literature:: Multi-step reaction with 2 steps

1: 1,4-dioxane / 7 h / 100 °C

2: sodium methylate / methanol / 6 h / 80 °C

With sodium methylate; In 1,4-dioxane; methanol;
DOI:10.1016/j.bmcl.2012.08.070