(2S^,6R^)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one

Base Information

Chemical Name:(2S^*,6R^*)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one
CAS No.:122624-16-2
Molecular Formula:C₂₂H₃₁NO
Molecular Weight:325.494
Hs Code.:

(2S<sup>*</sup>,6R<sup>*</sup>)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one

Synonyms:

Suppliers and Price of (2S^*,6R^*)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S^*,6R^*)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S^*,6R^*)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one

There total 26 articles about (2S^*,6R^*)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 122624-24-2
(2R^*,6R^*)-1-benzyl-2-(3-oxobutyl)-6-pentylpiperidine-2-carbaldehyde

: 122624-16-2,122624-17-3
(2R^*,6R^*)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; for 12h; Ambient temperature;
DOI:10.1021/jo00279a034

Reference yield:

: 32362-97-3
2-pentylcyclohexanone

: 122624-16-2,122624-17-3
(2R^*,6R^*)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one

Guidance literature:: Multi-step reaction with 14 steps

1: 71 percent / hydroxylamine-O-sulfonic acid, formic acid / 1 h / Heating

2: 1.) t-BuOK / 1.) THF, RT, 10 min, 2.) THF, reflux, 1 h

3: 95 percent / Lawesson's reagent / hexamethylphosphoric acid triamide / 2.5 h / 100 °C

5: 2.) triethylamine / 1.) 65-70 deg C, 3 h, 2.) dichloromethane, RT, 1 h

6: 98 percent / Raney nickel W₂ / acetone / 4 h / Heating

7: 1.) bromine, 2.) water, triethylamine / 1.) ether, dichloromethane, -70 deg C, 1.5 h, 2.) RT, 2 h

8: 59 percent / toluene / 40 h / 110 °C

9: H₂, KOH / 5percent Pd/C / ethyl acetate; ethanol / 0.58 h / Ambient temperature

10: 82 percent / p-toluenesulfonic acid / toluene / 6 h / Heating

11: Dibal / diethyl ether; toluene / 6 h / -78 °C

12: oxalyl chloride, dimethyl sulfoxide / CH₂Cl₂ / 0.5 h / -60 °C

13: 4 M HCl / 3 h

14: 73 percent / t-BuOK / tetrahydrofuran / 12 h / Ambient temperature

With Lawessons reagent; hydrogenchloride; potassium hydroxide; formic acid; oxalyl dichloride; potassium tert-butylate; water; hydrogen; bromine; diisobutylaluminium hydride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine; hydroxylamine-O-sulfonic acid; palladium on activated charcoal; Raney nickel W₂; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane; ethyl acetate; acetone; toluene;
DOI:10.1021/jo00279a034

Reference yield:

: 32362-97-3
2-pentylcyclohexanone

: 122624-16-2,122624-17-3
(2S^*,6R^*)-1-benzyl-2-pentyl-1-azaspiro<5.5>undec-7-en-9-one

Guidance literature:: Multi-step reaction with 11 steps

1: 71 percent / hydroxylamine-O-sulfonic acid, formic acid / 1 h / Heating

2: 1.) t-BuOK / 1.) THF, RT, 10 min, 2.) THF, reflux, 1 h

3: 95 percent / Lawesson's reagent / hexamethylphosphoric acid triamide / 2.5 h / 100 °C

4: 2.) 2 N HCl / 1.) 150 deg C, 5 h, 2.) RT, overnight

5: 2.) triethylamine / 1.) dichloromethane, RT, overnight, 2.) RT, 1 h

6: 82 percent / Raney nickel W₂ / acetone / 2 h / Heating

7: 1.) bromine, 2.) triethylamine / 1.) ether, -70 deg C, 1.5 h, 2.) RT, 48 h

8: 68 percent / t-BuOK / tetrahydrofuran / 2 h / Ambient temperature

9: H₂, KOH / 5percent Pd/C / ethyl acetate; ethanol / 0.58 h / 760 Torr / Ambient temperature

10: 87 percent / p-toluenesulfonic acid / benzene; acetone / 12 h / 50 °C

11: t-BuOK / tetrahydrofuran / 12 h / Ambient temperature

With Lawessons reagent; hydrogenchloride; potassium hydroxide; formic acid; potassium tert-butylate; hydrogen; bromine; toluene-4-sulfonic acid; triethylamine; hydroxylamine-O-sulfonic acid; palladium on activated charcoal; Raney nickel W₂; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; ethyl acetate; acetone; benzene;
DOI:10.1021/jo00279a034