Chemical Property of (2-iodo-5-nitrophenyl)(1-((1-methylpiperidin-2-yl)methyl)-1H-indol-3-yl)methanone
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:1.696
- Boiling Point:630.709 °C at 760 mmHg
- PKA:9.73±0.10(Predicted)
- Flash Point:335.241 °C
- PSA：71.06000
- Density:1.606 g/cm3
- LogP:5.33050
- Solubility.:DMSO: ~18mg/mL at 60°C
- XLogP3:4.7
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:4
- Rotatable Bond Count:4
- Exact Mass:503.07059
- Heavy Atom Count:29
- Complexity:613
- Purity/Quality:
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(R,S)-AM1241 ≥98% (HPLC), solid *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
36/37/38-42/43
- Safety Statements:
22-26-36/37-45
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CN1CCCCC1CN2C=C(C3=CC=CC=C32)C(=O)C4=C(C=CC(=C4)[N+](=O)[O-])I
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Description
AM1241 is a cannabinoid (CB) receptor agonist that is selective for CB2 over CB1 with Ki values of 7.1 and 580 nM for human recombinant receptors transfected into HEK and CHO cells, respectively, in a radioligand binding assay. It is considered a protean agonist as it has neutral antagonist and partial agonist activity, depending on the assay utilized. It is also acts in a species-dependent manner in vitro, acting as an agonist at human CB2 receptors (EC50 = 190 nM) but an inverse agonist at rat and mouse CB2 receptors (EC50s = 216 and 463 nM, respectively). AM1241 produces antinociception to thermal stimuli in rat hindpaw. The antinociceptive actions of AM1241 were blocked by the CB2 receptor-selective antagonist AM630 but not by the CB1 receptor-selective antagonist AM251 . AM1241 is neuroprotective, preventing HIV-1 glycoprotein Gp120-induced apoptosis in primary human and murine neural progenitor cells and increasing cell survival and differentiation. It increases hippocampal neurogenesis and decreases astro- and gliogenesis in GFAP/Gp120 transgenic mice when administered at a dose of 10 mg/kg daily for ten days. AM1241 also delays motor impairment in a murine model of amytrophic lateral sclerosis (ALS).
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Uses
(R,S)-AM1241 has been used as a cannabinoid CB2 agonist: to study its inhibitory effect on bone cancer-induced pain and bone loss to study the effect of its interaction with 17βestradiol on proliferation activity in primary human osteoblasts to evaluate the sites of CB2 mediated antinociception in vivo. (2-Iodo-5-nitrophenyl)[1-[(1-methyl-2-piperidinyl)methyl]-1H-indol-3-yl]methanone is a compound from the aminkalkylindole family which exerts potent and selective agonist activity for the cannabinoid
receptor CB2.
