1-[N-(p-Methoxyphenylsulfonyl)indol-2-yl]-2-phenylsulfonylacetylene

Base Information

Chemical Name:1-[N-(p-Methoxyphenylsulfonyl)indol-2-yl]-2-phenylsulfonylacetylene
CAS No.:334701-06-3
Molecular Formula:C₂₃H₁₇NO₅S₂
Molecular Weight:451.524
Hs Code.:

Synonyms:

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Chemical Property of 1-[N-(p-Methoxyphenylsulfonyl)indol-2-yl]-2-phenylsulfonylacetylene

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Technology Process of 1-[N-(p-Methoxyphenylsulfonyl)indol-2-yl]-2-phenylsulfonylacetylene

There total 5 articles about 1-[N-(p-Methoxyphenylsulfonyl)indol-2-yl]-2-phenylsulfonylacetylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: phosphoric acid 2-benzenesulfonyl-1-[1-(4-methoxy-benzenesulfonyl)-1H-indol-2-yl]-vinyl ester diethyl ester

: 334701-06-3
1-[N-(p-Methoxyphenylsulfonyl)indol-2-yl]-2-phenylsulfonylacetylene

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -78 ℃;
DOI:10.1039/b009154p

Reference yield:

: 128721-40-4
1-((4-methoxyphenyl)sulfonyl)-1H-indole

: 334701-06-3
1-[N-(p-Methoxyphenylsulfonyl)indol-2-yl]-2-phenylsulfonylacetylene

Guidance literature:: Multi-step reaction with 5 steps

1.1: BuLi / tetrahydrofuran / 0.08 h / 20 °C

1.2: 62 percent / tetrahydrofuran / -78 - 20 °C

2.1: SOCl₂ / 4 h / 40 °C

3.1: BuLi / tetrahydrofuran / 0.5 h / -30 °C

3.2: 50 percent / tetrahydrofuran / 1 h / -30 °C

4.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

4.2: tetrahydrofuran / 4 h / 20 °C

5.1: t-BuOK / tetrahydrofuran / -78 °C

With n-butyllithium; thionyl chloride; potassium tert-butylate; sodium hydride; In tetrahydrofuran;
DOI:10.1039/b009154p

Reference yield:

: 334701-11-0
N-(4-methoxybenzenesulfonyl)indole-2-carboxylic acid

: 334701-06-3
1-[N-(p-Methoxyphenylsulfonyl)indol-2-yl]-2-phenylsulfonylacetylene

Guidance literature:: Multi-step reaction with 4 steps

1.1: SOCl₂ / 4 h / 40 °C

2.1: BuLi / tetrahydrofuran / 0.5 h / -30 °C

2.2: 50 percent / tetrahydrofuran / 1 h / -30 °C

3.1: NaH / tetrahydrofuran / 0.5 h / 20 °C

3.2: tetrahydrofuran / 4 h / 20 °C

4.1: t-BuOK / tetrahydrofuran / -78 °C

With n-butyllithium; thionyl chloride; potassium tert-butylate; sodium hydride; In tetrahydrofuran;
DOI:10.1039/b009154p