5'-O-(4,4'-DiMethoxy)- 3'-O-(t-butyldiMethylsilyl) uridine, 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite

Base Information

Chemical Name:5'-O-(4,4'-DiMethoxy)- 3'-O-(t-butyldiMethylsilyl) uridine, 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite
CAS No.:129451-77-0
Molecular Formula:C₄₅H₆₁N₄O₉PSi
Molecular Weight:861.06
Hs Code.:
DSSTox Substance ID:DTXSID001100582
Mol file:129451-77-0.mol

Synonyms:129451-77-0;5'-O-DMT-3'-O-tert-Butyldimethylsilyl-uridine-2'-CE phosphoramidite;(2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite;3-[[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile;DTXSID001100582;AC-32400;A900275;Uridine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 2'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite];Uridine,5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-,2'-[2-cyanoethylN,N-bis(1-methylethyl)phosphoramidite]

Suppliers and Price of 5'-O-(4,4'-DiMethoxy)- 3'-O-(t-butyldiMethylsilyl) uridine, 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3''-O-tert-Butyldimethylsilyl-uridine-5''-O-DMT-2''-CEPhosphoramidite
200mg
$ 200.00

TRC
3''-O-tert-Butyldimethylsilyl-uridine-5''-O-DMT-2''-CEPhosphoramidite
50mg
$ 60.00

Biosynth Carbosynth
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 2'-CE phosphoramidite
100 mg
$ 60.00

Biosynth Carbosynth
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 2'-CE phosphoramidite
2 g
$ 450.00

Biosynth Carbosynth
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine 2'-CE phosphoramidite
1 g
$ 350.00

AK Scientific
3-[[(2R,3R,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
1g
$ 522.00

AK Scientific
3-[[(2R,3R,4R,5R)-5-[[Bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-[tert-butyl(dimethyl)silyl]oxy-2-(2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile
500mg
$ 320.00

Total 13 raw suppliers

Chemical Property of 5'-O-(4,4'-DiMethoxy)- 3'-O-(t-butyldiMethylsilyl) uridine, 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite

Chemical Property:

PKA:9.39±0.10(Predicted)
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:20
Exact Mass:860.39454307
Heavy Atom Count:60
Complexity:1430

Purity/Quality:

97% ^*data from raw suppliers

3''-O-tert-Butyldimethylsilyl-uridine-5''-O-DMT-2''-CEPhosphoramidite ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)N(C(C)C)P(OCCC#N)OC1C(C(OC1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[Si](C)(C)C(C)(C)C
Isomeric SMILES:CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COC(C3=CC=CC=C3)(C4=CC=C(C=C4)OC)C5=CC=C(C=C5)OC)O[Si](C)(C)C(C)(C)C
Uses 3''-O-tert-Butyldimethylsilyl-uridine-5''-O-DMT-2''-CE phosphoramidite is a uridine (U829910) derivative used in the preparation of synthetic RNA in the solid-phase.

Technology Process of 5'-O-(4,4'-DiMethoxy)- 3'-O-(t-butyldiMethylsilyl) uridine, 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite

There total 2 articles about 5'-O-(4,4'-DiMethoxy)- 3'-O-(t-butyldiMethylsilyl) uridine, 2'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoraMidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%