trans-4,5,5a,6,7,8,9,9a-Octahydrothiazolo(4,5-f)quinolin-2-amine

Base Information

Chemical Name:trans-4,5,5a,6,7,8,9,9a-Octahydrothiazolo(4,5-f)quinolin-2-amine
CAS No.:153260-24-3
Molecular Formula:C₁₀H₁₅N₃S
Molecular Weight:209.315
Hs Code.:
UNII:H23G951FGC
DSSTox Substance ID:DTXSID80165303
Nikkaji Number:J423.210K
Wikidata:Q27279533
Mol file:153260-24-3.mol

Synonyms:trans-4,5,5a,6,7,8,9,9a-Octahydrothiazolo(4,5-f)quinolin-2-amine;153260-24-3;H23G951FGC;(5aS,9aR)-4,5,5a,6,7,8,9,9a-octahydro-[1,3]thiazolo[4,5-f]quinolin-2-amine;4,5,5a,6,7,8,9,9a-Octahydro thiazolo(4,5-f)quinolin-2-amine, trans-;CCRIS 6700;UNII-H23G951FGC;TRANS-4,5,5A,6,7,8,9,9A-OCTAHYDROTHIAZOLO[4,5-F]QUINOLIN-2-AMINE;SCHEMBL10666367;DTXSID80165303;Q27279533;trans-4,5,5a,6,7,8,9,9a-octahydro thiazolo(4,5-f)quinolin-2-amine;THIAZOLO(4,5-F)QUINOLIN-2-AMINE, 4,5,5A,6,7,8,9,9A-OCTAHYDRO-, TRANS-

Suppliers and Price of trans-4,5,5a,6,7,8,9,9a-Octahydrothiazolo(4,5-f)quinolin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TRANS-4,5,5A,6,7,8,9,9A-OCTAHYDROTHIAZOLO(4,5-F)QUINOLIN-2-AMINE 95.00%
5MG
$ 502.04

Total 1 raw suppliers

Chemical Property of trans-4,5,5a,6,7,8,9,9a-Octahydrothiazolo(4,5-f)quinolin-2-amine

Chemical Property:

Vapor Pressure:9.18E-07mmHg at 25°C
Boiling Point:404.8°C at 760 mmHg
Flash Point:198.6°C
PSA：79.91000
Density:1.236g/cm³
LogP:1.76600
XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:0
Exact Mass:209.09866866
Heavy Atom Count:14
Complexity:223

Purity/Quality:: TRANS-4,5,5A,6,7,8,9,9A-OCTAHYDROTHIAZOLO(4,5-F)QUINOLIN-2-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC2C(CCC3=C2N=C(S3)N)NC1
Isomeric SMILES:C1C[C@@H]2[C@H](CCC3=C2N=C(S3)N)NC1

Technology Process of trans-4,5,5a,6,7,8,9,9a-Octahydrothiazolo(4,5-f)quinolin-2-amine

There total 8 articles about trans-4,5,5a,6,7,8,9,9a-Octahydrothiazolo(4,5-f)quinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 115689-07-1,115689-11-7
(+/-)-trans-2-amino-5,5a,7,8,9,9a-hexahydrothiazolo<4,5-f>quinoline-6(4H)-carboxylic acid 1,1-dimethylethyl ester

: 135311-96-5,153260-24-3
(+/-)-trans-4,5,5a,6,7,8,9,9a-octahydrothiazolo<4,5-f>quinolin-2-amine

Guidance literature:: With hydrogenchloride; In methanol; chloroform; for 24h; Ambient temperature;
DOI:10.1021/jm00113a010

Reference yield:

: 1006-51-5
2,3,4,6,7,8-hexahydro-5(1H)-quinolinone

: 135311-96-5,153260-24-3
(+/-)-trans-4,5,5a,6,7,8,9,9a-octahydrothiazolo<4,5-f>quinolin-2-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 36 percent / H₂, glacial acetic acid / PtO₂ / 75 h / 50 °C / 23271.7 Torr

2: 96 percent / 6 N aq. NaOH / tetrahydrofuran; H₂O / 12 h / Ambient temperature

3: 37 percent / pyridine dichromate / CH₂Cl₂ / 72 h / 25 °C

4: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 3 h, 2.) THF, -78 deg C, 2 h

5: N-bromosuccinimide (NBS) / CCl₄ / 1 h / Heating

6: methanol / 2 h / Heating

7: 90 percent / 1 N etheral HCl / methanol; CHCl₃ / 24 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; pyridinium dichromate; hydrogen; acetic acid; lithium diisopropyl amide; platinum(IV) oxide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; chloroform; water;
DOI:10.1021/jm00113a010

Reference yield:

: 92187-37-6
decahydro-5-quinolinol

: 135311-96-5,153260-24-3
(+/-)-trans-4,5,5a,6,7,8,9,9a-octahydrothiazolo<4,5-f>quinolin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / 6 N aq. NaOH / tetrahydrofuran; H₂O / 12 h / Ambient temperature

2: 37 percent / pyridine dichromate / CH₂Cl₂ / 72 h / 25 °C

3: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 3 h, 2.) THF, -78 deg C, 2 h

4: N-bromosuccinimide (NBS) / CCl₄ / 1 h / Heating

5: methanol / 2 h / Heating

6: 90 percent / 1 N etheral HCl / methanol; CHCl₃ / 24 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; N-Bromosuccinimide; pyridinium dichromate; lithium diisopropyl amide; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; chloroform; water;
DOI:10.1021/jm00113a010