7-BROMO-ISOQUINOLIN-1-YLAMINE

Base Information

• Chemical Name: 7-BROMO-ISOQUINOLIN-1-YLAMINE
• CAS No.: 215453-53-5
• Molecular Formula: C9H7BrN2
• Molecular Weight: 223.072
• Hs Code.: 2933499090
• Mol file: 215453-53-5.mol

Synonyms:1-Amino-7-bromoisoquinoline;

Chemical Property of 7-BROMO-ISOQUINOLIN-1-YLAMINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.732
• Boiling Point: 380.697 °C at 760 mmHg
• PKA: 6.74±0.33(Predicted)
• Flash Point: 184.039 °C
• PSA: 38.91000
• Density: 1.649 g/cm³
• LogP: 3.16070
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%min ^*data from raw suppliers

1-Amino-7-bromoisoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BROMO-ISOQUINOLIN-1-YLAMINE

There total 5 articles about 7-BROMO-ISOQUINOLIN-1-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.7%

7-bromo-1-chloroisoquinoline (215453-51-3) → 7-bromoisoquinolin-1-amine (215453-53-5)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; ammonium hydroxide; In water; at 148 ℃; for 20h; Sealed tube;

DOI:10.1021/acsmedchemlett.5b00174

Reference yield: 72.0%

C14H10BrN2(1+)*C2F3O2(1-) → 7-bromoisoquinolin-1-amine (215453-53-5)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 1h;

DOI:10.1055/s-0040-1719865

Reference yield:

7-bromo-1-hydroxyisoquinoline (223671-15-6) → 7-bromoisoquinolin-1-amine (215453-53-5)

Guidance literature:

With ammonium acetate; at 150 ℃; for 14h;

DOI:10.1016/S0960-894X(99)00483-7

upstream raw materials:

7-bromo-1-hydroxyisoquinoline

7-bromo-1-chloroisoquinoline

7-bromo-isoquinoline N-oxide

Downstream raw materials:

N-(7-bromo-1-isoquinolinyl)benzamide

1-(tert-butoxycarbonylamino)-7-(3-fluorophenyl)isoquinoline-4-carboxylic acid

tert-butyl (7-(3-fluorophenyl)-4-((3-oxocyclobutyl)carbamoyl)isoquinolin-1-yl)carbamate

4-bromo-7-(3-fluorophenyl)isoquinolin-1-amine

Refernces

• 1、 -. "AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF". Paragraph 0188. . Retrieved 2018/12/02.
• 2、 -. "Heterocyclic derivatives and their use as antithrombotic agents". . . Retrieved 2008/06/13.