2-(4-tert-Butyl-benzoylamino)-5-(5-hydroxy-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester

Base Information

• Chemical Name: 2-(4-tert-Butyl-benzoylamino)-5-(5-hydroxy-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester
• CAS No.: 75459-70-0
• Molecular Formula: C₃₈H₃₉N₃O₈S
• Molecular Weight: 697.809
• Mol file: 75459-70-0.mol

Synonyms:

Chemical Property of 2-(4-tert-Butyl-benzoylamino)-5-(5-hydroxy-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-tert-Butyl-benzoylamino)-5-(5-hydroxy-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester

There total 3 articles about 2-(4-tert-Butyl-benzoylamino)-5-(5-hydroxy-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-tert-Butyl-benzoylamino)-5-(1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester (75459-65-3) → 2-(4-tert-Butyl-benzoylamino)-5-(5-hydroxy-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester (75459-70-0)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dimethylformamide / Ambient temperature

2: 39.7 percent / bromine / dimethylformamide / 0 °C

3: dimethylsulfoxide / Ambient temperature

With bromine; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1248/cpb.28.1339

Reference yield:

2-(4-tert-Butyl-benzoylamino)-5-(1-oxo-7-trimethylsilanyloxy-2,2a-dihydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester → 2-(4-tert-Butyl-benzoylamino)-5-(5-hydroxy-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester (75459-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 39.7 percent / bromine / dimethylformamide / 0 °C

2: dimethylsulfoxide / Ambient temperature

With bromine; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1248/cpb.28.1339

Reference yield:

5-(5-Bromo-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-2-(4-tert-butyl-benzoylamino)-pentanoic acid benzhydryl ester (75459-68-6) → 2-(4-tert-Butyl-benzoylamino)-5-(5-hydroxy-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester (75459-70-0)

Guidance literature:

In dimethyl sulfoxide; Ambient temperature;

DOI:10.1248/cpb.28.1339

upstream raw materials:

5-(5-Bromo-1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-2-(4-tert-butyl-benzoylamino)-pentanoic acid benzhydryl ester

2-(4-tert-Butyl-benzoylamino)-5-(1,7-dioxo-2,2a,5,7-tetrahydro-1H,4H-6-oxa-3-thia-7b-aza-cyclobuta[e]inden-2-ylcarbamoyl)-pentanoic acid benzhydryl ester

Downstream raw materials:

7-[5-Benzhydryloxycarbonyl-5-(4-tert-butyl-benzoylamino)-pentanoylamino]-3-formyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester