1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-t-butoxycarbonylpyrrol-2-yl>-propane-2,2-dicarbonitrile

Base Information

• Chemical Name: 1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-t-butoxycarbonylpyrrol-2-yl>-propane-2,2-dicarbonitrile
• CAS No.: 101210-30-4
• Molecular Formula: C₄₀H₄₆N₄O₁₂
• Molecular Weight: 774.825
• Mol file: 101210-30-4.mol

Synonyms:

Chemical Property of 1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-t-butoxycarbonylpyrrol-2-yl>-propane-2,2-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-t-butoxycarbonylpyrrol-2-yl>-propane-2,2-dicarbonitrile

There total 4 articles about 1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-t-butoxycarbonylpyrrol-2-yl>-propane-2,2-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-chloromethyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester (51912-03-9) → 1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-t-butoxycarbonylpyrrol-2-yl>-propane-2,2-dicarbonitrile (101210-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1: Huenig's base

2: Huenig's base

DOI:10.1039/c39850001294

Reference yield:

5-Chloromethyl-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester (101210-29-1) + Benzyl 5-(2,2-Dicyanoethyl)-4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrole-2-carboxylate (101210-28-0) → 1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-t-butoxycarbonylpyrrol-2-yl>-propane-2,2-dicarbonitrile (101210-30-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h;

Reference yield:

tert-Butyl 5-methyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrole-2-carboxylate (70988-61-3) → 1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethyl-5-t-butoxycarbonylpyrrol-2-yl>-propane-2,2-dicarbonitrile (101210-30-4)

Guidance literature:

Multi-step reaction with 2 steps

1: sulphuryl chloride, CaCO₃ / CH₂Cl₂ / 0.33 h / 0 °C

2: 14 g / Hunig's base / CH₂Cl₂ / 1 h

With sulfuryl dichloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; In dichloromethane;

upstream raw materials:

5-Chloromethyl-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester

Benzyl 5-(2,2-Dicyanoethyl)-4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrole-2-carboxylate

5-chloromethyl-4-(2-methoxycarbonyl-ethyl)-3-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester

tert-Butyl 5-methyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrole-2-carboxylate

Downstream raw materials:

1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<5-<5-formyl-4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrol-2-ylmethyl>-4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrol-2-yl>propane-2,2-dicarboni

1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methyloxycarbonylmethylpyrrol-2-yl>-3-<5-iodo-4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrol-2-yl>-2,2-dicyanopropane-2,2-dicarbonitrile

1-<5-Benzyloxycarbonyl-3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethylpyrrol-2-yl>-3-<4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrol-2-yl>propane-2,2-dicarbonitrile

1--3-<5-carboxy-4-(2-methoxycarbonylethyl)-3-methoxycarbonylmethylpyrrol-2-yl>propane-2,2-dicarbonitrile