N-Ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Base Information

Chemical Name:N-Ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide
CAS No.:84088-99-3
Molecular Formula:C19H18N2O3
Molecular Weight:322.364
Hs Code.:

Synonyms:deschloro laquinimod;N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide;N-ETHYL-4-HYDROXY-1-METHYL-2-OXO-N-PHENYL-1,2-DIHYDROQUINOLINE-3-CARBOXAMIDE;

Suppliers and Price of N-Ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of N-Ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Chemical Property:

PSA：62.54000
LogP:2.91080

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-Ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

There total 4 articles about N-Ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57931-81-4
1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxylic acid

: 103-69-5
N-ethyl-N-phenylamine

: 84088-99-3
N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: With thionyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 5 ℃; for 3h;

Reference yield:

: 10328-92-4
N-Methylisatoic anhydride

: 84088-99-3
N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / N,N-dimethyl-formamide / 25 - 85 °C / Inert atmosphere

1.2: 0.5 h / 80 - 85 °C / Inert atmosphere

1.3: 25 - 30 °C / pH 1

2.1: hydrogenchloride; acetic acid / 2 h / 80 - 85 °C

3.1: thionyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 5 °C

With hydrogenchloride; thionyl chloride; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 118-48-9
isatoic anhydride

: 84088-99-3
N-ethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 0 - 30 °C

2.1: sodium methylate / N,N-dimethyl-formamide / 25 - 85 °C / Inert atmosphere

2.2: 0.5 h / 80 - 85 °C / Inert atmosphere

2.3: 25 - 30 °C / pH 1

3.1: hydrogenchloride; acetic acid / 2 h / 80 - 85 °C

4.1: thionyl chloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 - 5 °C

With hydrogenchloride; thionyl chloride; sodium methylate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;