PI3K inhibitor

Base Information

Chemical Name:PI3K inhibitor
CAS No.:1202884-94-3
Molecular Formula:C31H35F3N8O3
Molecular Weight:624.66
Hs Code.:
Mol file:1202884-94-3.mol

Synonyms:N-[2-(dimethylamino)ethyl]-N-methyl-4-[[[4-[4-(morpholin-4-yl)-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]carbamoyl]amino]benzamide;

Suppliers and Price of PI3K inhibitor

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
CAY10626
2.5mg
$ 295.00

Cayman Chemical
CAY10626 ≥98%
25mg
$ 1470.00

Cayman Chemical
CAY10626 ≥98%
5mg
$ 378.00

Cayman Chemical
CAY10626 ≥98%
1mg
$ 84.00

Cayman Chemical
CAY10626 ≥98%
10mg
$ 672.00

American Custom Chemicals Corporation
N-[2-(DIMETHYLAMINO)ETHYL]-N-METHYL-4-[[[[4-[4-(4-MORPHOLINYL)-7-(2,2,2-TRIFLUOROETHYL)-7H-PYRROLO-[2,3-D]PYRIMIDIN-2-YL]PHENYL]AMINO]CARBONYL]AMINO]-BENZAMIDE 95.00%
5MG
$ 495.61

AK Scientific
N-[2-(Dimethylamino)ethyl]-N-methyl-4-[[4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]carbamoylamino]benzamide
25mg
$ 2084.00

AK Scientific
N-[2-(Dimethylamino)ethyl]-N-methyl-4-[[4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)pyrrolo[2,3-d]pyrimidin-2-yl]phenyl]carbamoylamino]benzamide
10mg
$ 1007.00

Total 6 raw suppliers

Chemical Property of PI3K inhibitor

Chemical Property:

PKA:13.74±0.70(Predicted)
PSA：107.86000
Density:1.35±0.1 g/cm3(Predicted)
LogP:4.98580

Purity/Quality:

98%Min ^*data from raw suppliers

CAY10626 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description The PI3Kinases are important downstream effectors of KRAS signaling. In preclinical studies, buparlisib (BKM120), a PI3K inhibitor, when combined with MEK inhibitor (PD1056309) led to significant synergistic activity in KRAS mutant NSCLC cell lines.

Technology Process of PI3K inhibitor

There total 1 articles about PI3K inhibitor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202885-81-1
4-({[4-(7-(2,2,2-trifluoroethyl)-4-morpholin-4-yl-7H-pyrrolo-[2,3-d]pyrimidin-2-yl)phenyl]carbamoyl}amino)benzoic acid

: 142-25-6
N,N',N'-trimethylenediamine

: 1202884-94-3
N-[2-(dimethylamino)ethyl]-N-methyl-4-[({4-[4-morpholin-4-yl-7-(2,2,2-trifluoroethyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]phenyl}carbamoyl)amino]benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; at 20 ℃;