Technology Process of 2-((R)-9-tert-Butoxycarbonylmethyl-8-oxo-2,3,6,7,8,9-hexahydro-1H-5-thia-9-aza-cyclohepta[f]inden-7-ylamino)-4-phenyl-butyric acid ethyl ester
There total 9 articles about 2-((R)-9-tert-Butoxycarbonylmethyl-8-oxo-2,3,6,7,8,9-hexahydro-1H-5-thia-9-aza-cyclohepta[f]inden-7-ylamino)-4-phenyl-butyric acid ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 6.1 percent / NaNO2 / Ambient temperature
2: 58 percent / Na2CO3 / H2O / 5 h / Ambient temperature
3: H2 / 5 percent Pd-C / methanol / Ambient temperature
4: DEPC, Et3N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.
5: 69 percent / NaH / dimethylformamide / 0.33 h
6: 69 percent / N2H4*H2O / ethanol / 1 h / Heating
7: NaBH3CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature
With
4 A molecular sieve; hydrogen; sodium hydride; sodium cyanoborohydride; sodium carbonate; hydrazine hydrate; triethylamine; diethyl dicarbonate; sodium nitrite;
palladium on activated charcoal;
In
methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 58 percent / Na2CO3 / H2O / 5 h / Ambient temperature
2: H2 / 5 percent Pd-C / methanol / Ambient temperature
3: DEPC, Et3N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.
4: 69 percent / NaH / dimethylformamide / 0.33 h
5: 69 percent / N2H4*H2O / ethanol / 1 h / Heating
6: NaBH3CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature
With
4 A molecular sieve; hydrogen; sodium hydride; sodium cyanoborohydride; sodium carbonate; hydrazine hydrate; triethylamine; diethyl dicarbonate;
palladium on activated charcoal;
In
methanol; ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128
- Guidance literature:
-
Multi-step reaction with 5 steps
1: H2 / 5 percent Pd-C / methanol / Ambient temperature
2: DEPC, Et3N / dimethylformamide / 1) 35 min 0 deg C 2) 1 h r.t.
3: 69 percent / NaH / dimethylformamide / 0.33 h
4: 69 percent / N2H4*H2O / ethanol / 1 h / Heating
5: NaBH3CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature
With
4 A molecular sieve; hydrogen; sodium hydride; sodium cyanoborohydride; hydrazine hydrate; triethylamine; diethyl dicarbonate;
palladium on activated charcoal;
In
methanol; ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.34.1128
