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Mavoglurant

Base Information Edit
  • Chemical Name:Mavoglurant
  • CAS No.:543906-09-8
  • Molecular Formula:C19H23NO3
  • Molecular Weight:313.39
  • Hs Code.:
  • European Community (EC) Number:691-869-0
  • UNII:GT0I9SV4F6
  • DSSTox Substance ID:DTXSID30202777
  • Nikkaji Number:J3.300.754J
  • Wikipedia:Mavoglurant
  • Wikidata:Q6589598
  • NCI Thesaurus Code:C170154
  • Pharos Ligand ID:FWFCL7UGP1TT
  • Metabolomics Workbench ID:153884
  • ChEMBL ID:CHEMBL3087515
  • Mol file:543906-09-8.mol
Mavoglurant

Synonyms:AFQ056;mavoglurant

Suppliers and Price of Mavoglurant
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • Mavoglurant
  • 10mg
  • $ 445.00
  • DC Chemicals
  • Mavoglurant(AFQ056) >98%
  • 100 mg
  • $ 1100.00
  • DC Chemicals
  • Mavoglurant(AFQ056) >98%
  • 25 mg
  • $ 600.00
  • DC Chemicals
  • Mavoglurant(AFQ056) >98%
  • 10 mg
  • $ 350.00
  • CSNpharm
  • Mavoglurant
  • 1mg
  • $ 177.00
  • CSNpharm
  • Mavoglurant
  • 10mg
  • $ 432.00
  • Crysdot
  • Mavoglurant 98+%
  • 10mg
  • $ 768.00
  • Crysdot
  • Mavoglurant 98+%
  • 5mg
  • $ 378.00
  • ChemScene
  • Mavoglurant 99.99%
  • 10mg
  • $ 540.00
  • ChemScene
  • Mavoglurant 99.99%
  • 5mg
  • $ 420.00
Total 22 raw suppliers
Chemical Property of Mavoglurant Edit
Chemical Property:
  • Boiling Point:476.3±45.0 °C(Predicted) 
  • PKA:12.75±0.20(Predicted) 
  • PSA:49.77000 
  • Density:1.21 
  • LogP:2.65630 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO (Slightly), Methanol (Slightly) 
  • XLogP3:2.9
  • Hydrogen Bond Donor Count:1
  • Hydrogen Bond Acceptor Count:3
  • Rotatable Bond Count:3
  • Exact Mass:313.16779360
  • Heavy Atom Count:23
  • Complexity:519
Purity/Quality:

98%Min *data from raw suppliers

Mavoglurant *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
  • Canonical SMILES:CC1=CC(=CC=C1)C#CC2(CCCC3C2CCN3C(=O)OC)O
  • Isomeric SMILES:CC1=CC(=CC=C1)C#C[C@@]2(CCC[C@@H]3[C@H]2CCN3C(=O)OC)O
  • Recent ClinicalTrials:Mavoglurant in Alcohol Drinking
  • Recent EU Clinical Trials:A randomized, subject and investigator blinded, placebo-controlled, parallel group study to investigate whether AFQ056 reduces cocaine use in patients diagnosed with Cocaine Use Disorder (CUD).
  • Uses Mavoglurant is a non-competitive metabotropic glutamate receptor 5 (mGlu5) receptor antagonist.
Technology Process of Mavoglurant

There total 11 articles about Mavoglurant which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
(-)-(3aR,4S,7aR)-4-hydroxy-4-(m-tolylethynyl)-octahydro-indole hydrochloride; With triethylamine; In dichloromethane; at 5 ℃;
methyl chloroformate; In dichloromethane; for 2h;
DOI:10.1016/j.bmc.2014.09.033
Guidance literature:
(±)-(3aR,4S,7aR)-4-hydroxy-4-(m-tolylethynyl)-octahydro-indole hydrochloride; With triethylamine; In dichloromethane; at 0 ℃;
methyl chloroformate; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2014.09.033
Refernces Edit
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