trans-3-Methylcyclobutanecarboxylic acid

Base Information

• Chemical Name: trans-3-Methylcyclobutanecarboxylic acid
• CAS No.: 87863-09-0
• Molecular Formula: C6H10O2
• Molecular Weight: 114.14
• Hs Code.: 2916200090
• Mol file: 87863-09-0.mol

Synonyms:trans-3-Methylcyclobutanecarboxylic acid

Chemical Property of trans-3-Methylcyclobutanecarboxylic acid

Chemical Property:

• Boiling Point: 194.0±8.0 °C(Predicted)
• PKA: 4.81±0.40(Predicted)
• PSA: 37.30000
• Density: 1.105±0.06 g/cm3(Predicted)
• LogP: 1.11710

Purity/Quality:

98%,99%, ^*data from raw suppliers

trans-3-Methylcyclobutanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-3-Methylcyclobutanecarboxylic acid

There total 2 articles about trans-3-Methylcyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methyl-cyclobut-1-en-1-carbonsaeure (89533-69-7) → trans-3-Methylcyclobutancarbonsaeure (87863-09-0)

Guidance literature:

With hydrogenchloride; potassium hydroxide; zinc; Yield given. Multistep reaction; 1) THF, H₂O, reflux, 2 h 2) H₂O, EtOH, reflux;

Reference yield:

→ trans-3-Methylcyclobutancarbonsaeure (87863-09-0)

Guidance literature:

3-Methyl-cyclopentanon, SeO2, H2O2;

Reference yield: 8.9%

trans-3-Methylcyclobutancarbonsaeure (87863-09-0) + 6-ethyl-N-(pyridin-3-ylmethyl)benzo[d]thiazol-2-amine → (1s,3r)-N-(6-ethyl-1,3-benzothiazol-2-yl)-3-methyl-N-[(pyridin-3-yl)methyl]cyclobutane-1-carboxamide

Guidance literature:

With triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 10 ℃; for 17h;

upstream raw materials:

3-Methyl-cyclobut-1-en-1-carbonsaeure

Refernces