(6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine pentafluorophenyl ester

Base Information

• Chemical Name: (6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine pentafluorophenyl ester
• CAS No.: 1412697-60-9
• Molecular Formula: C₄₈H₅₅F₅N₆O₁₃
• Molecular Weight: 1018.99

Synonyms:

Chemical Property of (6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine pentafluorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine pentafluorophenyl ester

There total 6 articles about (6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,4,5,6-pentafluorophenol (771-61-9) + (6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine (1412697-00-7) → (6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine pentafluorophenyl ester (1412697-60-9)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1002/ejoc.201200463

Reference yield:

(6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine methyl ester (1412696-80-0) → (6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine pentafluorophenyl ester (1412697-60-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: water; barium(II) hydroxide / tetrahydrofuran / 3 h / 20 °C

2.1: O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h

2.2: 20 h / 20 °C / Inert atmosphere

3.1: water; barium(II) hydroxide / tetrahydrofuran / 3 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

With O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; barium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201200463

Reference yield:

6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonic acid (668990-26-9) → (6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine pentafluorophenyl ester (1412697-60-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h

1.2: 20 h / 20 °C / Inert atmosphere

2.1: water; barium(II) hydroxide / tetrahydrofuran / 3 h / 20 °C

3.1: O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 0.08 h

3.2: 20 h / 20 °C / Inert atmosphere

4.1: water; barium(II) hydroxide / tetrahydrofuran / 3 h / 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / 1,4-dioxane / 16 h / 20 °C / Inert atmosphere

With O-(benzotriazol-1-yl )-N,N,N' ,N'-tetramethyluronium tetrafluoroborate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; barium(II) hydroxide; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201200463

upstream raw materials:

6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonic acid

2,3,4,5,6-pentafluorophenol

(6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine

(6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine methyl ester

Downstream raw materials:

cyclo[(6-azido-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine-(6-amino-6-deoxy-2,3:4,5-di-O-isopropylidene-D-galactonyl)-L-phenylalanine]

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