8-Bromo-2,4-dichloroquinazoline

Base Information

• Chemical Name: 8-Bromo-2,4-dichloroquinazoline
• CAS No.: 331647-05-3
• Molecular Formula: C8H3BrCl2N2
• Molecular Weight: 275.89
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID70549436
• Wikidata: Q72454182
• Mol file: 331647-05-3.mol

Synonyms:8-bromo-2,4-dichloroquinazoline;331647-05-3;8-Bromo-2,4-dichloro-quinazoline;2,4-DICHLORO-8-BROMOQUINAZOLINE;MFCD09954891;Quinazoline, 8-bromo-2,4-dichloro-;SCHEMBL558543;DTXSID70549436;BHXJPWCPEFXWMH-UHFFFAOYSA-N;SC3551;AKOS015851271;8-Bromo-2 pound not4-dichloroquinazoline;AS-11130;SY029036;A5919;AM20040187;CS-0006433;EN300-263062;J-519380;Z1269146718

Chemical Property of 8-Bromo-2,4-dichloroquinazoline

Chemical Property:

• Vapor Pressure: 0.0388mmHg at 25°C
• Refractive Index: 1.696
• Boiling Point: 248.2 °C at 760 mmHg
• PKA: -1.75±0.30(Predicted)
• Flash Point: 103.9 °C
• PSA: 25.78000
• Density: 1.852 g/cm³
• LogP: 3.69910
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 275.88567
• Heavy Atom Count: 13
• Complexity: 193

Purity/Quality:

99% ^*data from raw suppliers

8-Bromo-2,4-dichloroquinazoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C(=C1)Br)N=C(N=C2Cl)Cl

Technology Process of 8-Bromo-2,4-dichloroquinazoline

There total 6 articles about 8-Bromo-2,4-dichloroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

8-bromoquinazoline-2,4-diol (331646-99-2) → 8-bromo-2,4-dichloroquinazoline (331647-05-3)

Guidance literature:

With dmap; trichlorophosphate; for 4h; Reflux;

Reference yield: 89.0%

8-bromoquinazoline-2,4-(1H,3H)-dione (331646-99-2) → 8-bromo-2,4-dichloroquinazoline (331647-05-3)

Guidance literature:

With N,N-diethylaniline; trichlorophosphate; for 4h; Inert atmosphere; Reflux;

DOI:10.1021/ol102915f

Reference yield: 71.0%

C8H5BrN2O2 → 8-bromo-2,4-dichloroquinazoline (331647-05-3)

Guidance literature:

With bis(trichloromethyl) carbonate; Tris(4-methoxyphenyl)phosphine oxide; In chlorobenzene; at 120 ℃; for 6h;

DOI:10.1080/10426507.2020.1782910

upstream raw materials:

8-bromoquinazoline-2,4-diol

8-bromoquinazoline-2,4-(1H,3H)-dione

2,6-dibromoaniline

2-amino-3-bromo-benzonitrile

Downstream raw materials:

8-bromo-2-chloroquinazolin-4-amine

Refernces

• 1、 Qin, Jinjing,Li, Zhenhua,Ma, Shengzhe,Ye, Lixian,Jin, Guoqiang,Su, Weike. "One-pot cascade ring enlargement of isatin-3-oximes to 2,4-dichloroquinazolines mediated by bis(trichloromethyl)carbonate and triarylphosphine oxide". supporting information. p. 1007 - 1012. Retrieved 2020/07/10.
• 2、 -. "CONDENSED-RING PYRIMIDYLAMINO DERIVATIVE, PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION AND APPLICATIONS THEREOF". Paragraph 0191; 0193. . Retrieved 2018/03/25.