diethyl N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxy-3'-O-acetyluridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamate 5'-(trichloroethyl methyl phosphate)

Base Information

Chemical Name:diethyl N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxy-3'-O-acetyluridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamate 5'-(trichloroethyl methyl phosphate)
CAS No.:88543-93-5
Molecular Formula:C₃₉H₅₀Cl₃N₈O₁₅P
Molecular Weight:1008.2
Hs Code.:

diethyl N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxy-3'-O-acetyluridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamate 5'-(trichloroethyl methyl phosphate)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxy-3'-O-acetyluridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamate 5'-(trichloroethyl methyl phosphate)

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Technology Process of diethyl N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxy-3'-O-acetyluridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamate 5'-(trichloroethyl methyl phosphate)

There total 1 articles about diethyl N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxy-3'-O-acetyluridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamate 5'-(trichloroethyl methyl phosphate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 88543-91-3
Acetic acid (2R,3S,5R)-5-(5-bromomethyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-2-[methoxy-(2,2,2-trichloro-ethoxy)-phosphoryloxymethyl]-tetrahydro-furan-3-yl ester

: 82855-85-4
diethyl 5,6,7,8-tetrahydro-8-deazafolate

: 88543-93-5,92008-89-4,92008-90-7
diethyl N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxy-3'-O-acetyluridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamate 5'-(trichloroethyl methyl phosphate)

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; for 6h; Ambient temperature;
DOI:10.1021/jm00378a031

Reference yield:

: 88543-93-5,92008-89-4,92008-90-7
diethyl N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxy-3'-O-acetyluridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamate 5'-(trichloroethyl methyl phosphate)

: 92008-02-1,92008-03-2
N-<4-<<<2-amino-3,4,5,6,7,8-hexahydro-4-oxo-5-<(2'-deoxyuridin-5-yl)methyl>pyrido<3,2-d>pyrimidin-6-yl>methyl>amino>benzoyl>-L-glutamic acid 5'-(methylphosphate)

Guidance literature:: With sodium hydroxide; copper; acetylacetone; zinc; Yield given. Multistep reaction; 1.) DMF, RT, 3 h, 2.) EtOH, 48 h;
DOI:10.1021/jm00378a031