Technology Process of C44H46N4O9S
There total 10 articles about C44H46N4O9S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: sodium hydroxide / water; tert-butyl alcohol / 20 °C
2: palladium 10% on activated carbon / 40 °C
3: 4-methyl-morpholine / acetonitrile / Cooling with ice
4: ethanol
5: hydrogenchloride; acetic acid / 1 h
6: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / pH 7 - 8 / Cooling with ice
With
4-methyl-morpholine; hydrogenchloride; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
ethanol; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1021/jm2011996
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 4-methyl-morpholine / acetonitrile / Cooling with ice
2.1: hydrogenchloride; acetic acid / 1 h
3.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Reflux
3.2: 5.58 h / 0 - 20 °C / pH 8 - 9
4.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / pH 7 - 8 / Cooling with ice
With
4-methyl-morpholine; hydrogenchloride; chloro-trimethyl-silane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm2011996
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogenchloride; acetic acid / 1 h
2.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Reflux
2.2: 5.58 h / 0 - 20 °C / pH 8 - 9
3.1: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 3 h / pH 7 - 8 / Cooling with ice
With
hydrogenchloride; chloro-trimethyl-silane; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm2011996
