(R)-Piperidine-2-carboxylic acid hydrochloride

Base Information

• Chemical Name: (R)-Piperidine-2-carboxylic acid hydrochloride
• CAS No.: 38470-14-3
• Molecular Formula: C6H12ClNO2
• Molecular Weight: 165.62
• Hs Code.: 2933399090
• UNII: 15W1B1WIPI
• Wikidata: Q27251748
• Mol file: 38470-14-3.mol

Synonyms:38470-14-3;(R)-PIPERIDINE-2-CARBOXYLIC ACID HYDROCHLORIDE;D-Pipercolic acid HCl;(+)-Pipecolinic acid hydrochloride;UNII-15W1B1WIPI;Pipecolic acid hydrochloride, (+)-;(R)-PIPERIDINE-2-CARBOXYLIC ACID HCL;15W1B1WIPI;2-Piperidinecarboxylic acid, hydrochloride (1:1), (2R)-;(2R)-piperidine-2-carboxylic acid;hydrochloride;(R)-Piperidine-2-carboxylic acid, HCl;D(+)-PIPECOLINIC ACID HYDROCHLORIDE;SCHEMBL4242563;MFCD00792495;AKOS017344021;D-PIPECOLINIC ACID HYDROCHLORIDE;(+)-PIPECOLIC ACID HYDROCHLORIDE;AS-38236;CS-0143812;Q27251748

Chemical Property of (R)-Piperidine-2-carboxylic acid hydrochloride

Chemical Property:

• Vapor Pressure: 0.000324mmHg at 25°C
• Boiling Point: 265.8 °C at 760 mmHg
• Flash Point: 114.5 °C
• PSA: 49.33000
• LogP: 1.34390
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 165.0556563
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

97% ^*data from raw suppliers

D-PipercolicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCNC(C1)C(=O)O.Cl
• Isomeric SMILES: C1CCN[C@H](C1)C(=O)O.Cl

Technology Process of (R)-Piperidine-2-carboxylic acid hydrochloride

There total 4 articles about (R)-Piperidine-2-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(2R)-N-acetyl-2-(methoxycarbonyl)piperidine (111956-95-7) → (2R)-pipecolinic acid hydrochloride (38470-14-3,5107-10-8)

Guidance literature:

With hydrogenchloride; In water; Heating;

DOI:10.1039/b209087m

Reference yield:

Piperidine-1,2-dicarboxylic acid 1-phenyl ester → (2S)-2-piperidinecarboxylic acid hydrochloride (2133-33-7,5107-10-8) + (2R)-pipecolinic acid hydrochloride (38470-14-3,5107-10-8)

Guidance literature:

With hydrogenchloride; hydrogen; platinum(IV) oxide; In methanol; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00114a006

Reference yield:

(2R)-methyl N-acetyl-5,6-didehydropipecolate (548490-89-7) → (2R)-pipecolinic acid hydrochloride (38470-14-3,5107-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / H₂ / Pd/C / methanol / 18 h / 4654.46 Torr

2: 89 percent / HCl / H₂O / Heating

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; water;

DOI:10.1039/b209087m

upstream raw materials:

(2R)-N-acetyl-2-(methoxycarbonyl)piperidine

(2R)-methyl N-acetyl-5,6-didehydropipecolate

(2Z)-methyl 2-N-acetylaminopenta-2,4-dienoate