6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester

Base Information

• Chemical Name: 6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester
• CAS No.: 317806-26-1
• Molecular Formula: C17H23NO6
• Molecular Weight: 337.3676
• Mol file: 317806-26-1.mol

Synonyms:6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLINE-2,3-DICARBOXYLIC ACID 2-TERT-BUTYL ESTER

Chemical Property of 6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester

Chemical Property:

• Vapor Pressure: 1.07E-10mmHg at 25°C
• Boiling Point: 497°C at 760 mmHg
• Flash Point: 254.4°C
• PSA: 85.30000
• Density: 1.227g/cm³
• LogP: 2.38810

Purity/Quality:

98%min ^*data from raw suppliers

2-(tert-Butoxycarbonyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester

There total 2 articles about 6,7-Dimethoxy-3,4-dihydro-1H-isoquinoline-2,3-dicarboxylic acid 2-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(t-butyloxycarbonyl)-3-methoxycarbonyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (317806-25-0) → 3,4-dihydro-6,7-dimethoxy-2,3(1H)-Isoquinolinedicarboxylic acid 2-(1,1-dimethylethyl) ester (317806-26-1)

Guidance literature:

In diethyl ether; water;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 3,4-dihydro-6,7-dimethoxy-2,3(1H)-Isoquinolinedicarboxylic acid 2-(1,1-dimethylethyl) ester (317806-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane; water

2: diethyl ether; water

In 1,4-dioxane; diethyl ether; water;

upstream raw materials:

N-(t-butyloxycarbonyl)-3-methoxycarbonyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

di-tert-butyl dicarbonate

Refernces