5-BROMO-4-PYRIMIDINECARBOXALDEHYDE

Base Information

• Chemical Name: 5-BROMO-4-PYRIMIDINECARBOXALDEHYDE
• CAS No.: 933746-26-0
• Molecular Formula: C5H3BrN2O
• Molecular Weight: 186.996
• Hs Code.: 2933599090
• Mol file: 933746-26-0.mol

Synonyms:5-BROMO-4-PYRIMIDINECARBOXALDEHYDE

Chemical Property of 5-BROMO-4-PYRIMIDINECARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Boiling Point: 281.522°C at 760 mmHg
• Flash Point: 124.06°C
• PSA: 42.85000
• Density: 1.803g/cm³
• LogP: 1.05160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

5-Bromopyrimidine-4-carbaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-BROMO-4-PYRIMIDINECARBOXALDEHYDE

There total 2 articles about 5-BROMO-4-PYRIMIDINECARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

5-bromopyrimidine-4-carboxylic acid methoxy-methylamide → 5-bromopyrimidine-4-carbaldehyde (933746-26-0)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -10 ℃; for 1h; Inert atmosphere;

Reference yield:

5-bromo-4-pyrimidine carboxylic acid (64224-60-8) → 5-bromopyrimidine-4-carbaldehyde (933746-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -10 °C / Inert atmosphere

With diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane;

Reference yield: 41.0%

5-bromopyrimidine-4-carbaldehyde (933746-26-0) + (1-trityl-1H-imidazol-4-yl)boronic acid (1900755-49-8) → 5-[1-(triphenylmethyl)-1H-imidazol-4-yl]pyrimidine-4-carbaldehyde

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 2h; Inert atmosphere;

upstream raw materials:

5-bromo-4-pyrimidine carboxylic acid

Downstream raw materials:

(5-bromopyrimidin-4-yl)-(4-(trifluoromethyl)phenyl)methanol

(E)-2-(2-(4-(hydroxy(4-(trifluoromethyl)phenyl)methyl)pyrimidin-5-yl)vinyl)isoindoline-1,3-dione

2-(2-(4-(4-(trifluoromethyl)benzoyl)pyrimidin-5-yl)ethyl) isoindoline-1,3-dione

8-(4-(trifluoromethyl)phenyl)-5,6-dihydropyrido[3,4-d]pyrimidine

Refernces