1-Methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

Base Information

• Chemical Name: 1-Methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one
• CAS No.: 84060-10-6
• Molecular Formula: C₁₃H₁₆N₂O₂
• Molecular Weight: 232.282
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID20516512
• Wikidata: Q82377977
• Mol file: 84060-10-6.mol

Synonyms:84060-10-6;1-Methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one;1-METHYLSPIRO[4H-3,1-BENZOXAZINE-4,4'-PIPERIDIN]-2(1H)-ONE;1-METHYLSPIRO[3,1-BENZOXAZINE-4,4'-PIPERIDINE]-2-ONE;SCHEMBL7654525;DTXSID20516512;CS-D1076;SB43883;FT-0648725;1-Methylspiro[3,1-benzoxazine-4,4'-piperidin]-2(1H)-one

Chemical Property of 1-Methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

Chemical Property:

• Boiling Point: 370.2oC at 760 mmHg
• Flash Point: 177.7oC
• PSA: 41.57000
• Density: 1.25g/cm3
• LogP: 2.24550
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 232.121177757
• Heavy Atom Count: 17
• Complexity: 313

Purity/Quality:

98%min ^*data from raw suppliers

1-Methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C2=CC=CC=C2C3(CCNCC3)OC1=O

Technology Process of 1-Methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one

There total 4 articles about 1-Methylspiro[benzo[d][1,3]oxazine-4,4'-piperidin]-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

C18H24N2O4 (345938-03-6) → C13H16N2O2 (84060-10-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 2h; Ambient temperature;

DOI:10.1021/jm00359a007

Reference yield:

tert-butyl phenylcarbamate (3422-01-3) → C13H16N2O2 (84060-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) t-bytyllithium, 2.) t-butoxide / 1.) pentane, THF, a) -70 deg, 0.5 h, b) -20 deg, 2.5 h, 2.) THF, a) from -70 deg to RT, 4 h, b) RT, 16 h

2: 1.) NaH / 1.) DMF, 20 deg, 0.5 h, 2.) DMF, 20 deg, 1 h

3: 78 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / Ambient temperature

With t-butoxide; tert.-butyl lithium; sodium hydride; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm00359a007

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → C13H16N2O2 (84060-10-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) t-bytyllithium, 2.) t-butoxide / 1.) pentane, THF, a) -70 deg, 0.5 h, b) -20 deg, 2.5 h, 2.) THF, a) from -70 deg to RT, 4 h, b) RT, 16 h

2: 1.) NaH / 1.) DMF, 20 deg, 0.5 h, 2.) DMF, 20 deg, 1 h

3: 78 percent / trifluoroacetic acid / CH₂Cl₂ / 2 h / Ambient temperature

With t-butoxide; tert.-butyl lithium; sodium hydride; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm00359a007

upstream raw materials:

C₁₈H₂₄N₂O₄

tert-butyl phenylcarbamate

N-tert-butyloxycarbonylpiperidin-4-one

4'-(tert-butoxycarbonyl)spiro<4H-3,1-benzoxazine-4,4'-piperidin>-2(1H)-one