7-BROMO-4-ISOCHROMANONE

Base Information

• Chemical Name: 7-BROMO-4-ISOCHROMANONE
• CAS No.: 168759-64-6
• Molecular Formula: C₉H₇BrO₂
• Molecular Weight: 227.057
• Hs Code.: 2932999099
• Mol file: 168759-64-6.mol

Synonyms:1H-2-benzopyran-4(3H)-one, 7-bromo-;7-Bromo-1H-isochromen-4(3H)-one;

Chemical Property of 7-BROMO-4-ISOCHROMANONE

Chemical Property:

• Vapor Pressure: 4.93E-05mmHg at 25°C
• Refractive Index: 1.599
• Boiling Point: 348.7 °C at 760 mmHg
• Flash Point: 164.7 °C
• PSA: 26.30000
• Density: 1.621 g/cm³
• LogP: 2.16200
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

7-Bromoisochroman-4-One ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-BROMO-4-ISOCHROMANONE

There total 14 articles about 7-BROMO-4-ISOCHROMANONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

4-bromo-2-((carboxymethoxy)methyl)benzoic acid → 7-bromoisochroman-4-one (168759-64-6)

Guidance literature:

4-bromo-2-((carboxymethoxy)methyl)benzoic acid; With potassium acetate; acetic anhydride; for 2h; Reflux;

With ethanol; sodium hydroxide; at 20 ℃; for 2h;

Reference yield:

C14H13BrO7 → 7-bromoisochroman-4-one (168759-64-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 2h;

Reference yield:

7-bromo-4-methyleneisochroman → 7-bromoisochroman-4-one (168759-64-6)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; water; at 0 - 20 ℃; for 1h;

upstream raw materials:

5-bromophthalide

4-bromo-2-(hydroxymethyl)benzoic acid

4-bromo-2-methylbenzonitrile

4-bromo-2-(bromomethyl)-benzonitrile

Downstream raw materials:

7-bromoisochroman-4-amine

Refernces

• 1、 -. "PPAR (peroxisome proliferator-activated receptor) agonist and application thereof to treatment of senile dementia and other diseases". . . Retrieved 2018/07/30.
• 2、 -. "ALDOSTERONE SYNTHASE INHIBITORS". . . Retrieved 2016/06/28.