4-Chloro-6,7-dimethoxy-2-methylquinazoline

Base Information

• Chemical Name: 4-Chloro-6,7-dimethoxy-2-methylquinazoline
• CAS No.: 50377-49-6
• Molecular Formula: C11H11ClN2O2
• Molecular Weight: 238.674
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40440789
• Wikidata: Q72518602
• Mol file: 50377-49-6.mol

Synonyms:4-chloro-6,7-dimethoxy-2-methylquinazoline;50377-49-6;Quinazoline, 4-chloro-6,7-dimethoxy-2-methyl-;MFCD11046864;SCHEMBL372259;DTXSID40440789;VHTOWTBCVHATEY-UHFFFAOYSA-N;BCP27293;AKOS005145992;DS-12010;SY239524;AM20040576;CS-0114111;FT-0706212;A15603;J-515087

Chemical Property of 4-Chloro-6,7-dimethoxy-2-methylquinazoline

Chemical Property:

• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.596
• Boiling Point: 286.837 °C at 760 mmHg
• Flash Point: 127.274 °C
• PSA: 44.24000
• Density: 1.282 g/cm³
• LogP: 2.60880
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 238.0509053
• Heavy Atom Count: 16
• Complexity: 242

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-6,7-dimethoxy-2-methyl-quinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=CC(=C(C=C2C(=N1)Cl)OC)OC

Technology Process of 4-Chloro-6,7-dimethoxy-2-methylquinazoline

There total 6 articles about 4-Chloro-6,7-dimethoxy-2-methylquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6,7-dimethoxy-2-methylquinazolin-4-ol (35241-23-7) → 4-chloro-6,7-dimethoxy-2-methylquinazoline (50377-49-6)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; at 80 ℃; for 1h; Temperature;

Reference yield: 92.0%

6,7-dimethoxy-2-methylquinazoline-4(3H)-one (35241-23-7) → 4-chloro-6,7-dimethoxy-2-methylquinazoline (50377-49-6)

Guidance literature:

With trichlorophosphate; for 3h; Reflux;

Reference yield:

methyl 2-amino-4,5-dimethoxybenzoate (26759-46-6) → 4-chloro-6,7-dimethoxy-2-methylquinazoline (50377-49-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / HCl gas / 8 h / Heating

2: 56 percent / POCl₃ / 8 h / Heating

With hydrogenchloride; trichlorophosphate;

DOI:10.1021/jm9503613

upstream raw materials:

6,7-dimethoxy-2-methylquinazoline-4(3H)-one

2-Amino-4,5-dimethoxybenzoic acid

methyl 2-amino-4,5-dimethoxybenzoate

6,7-dimethoxy-2-methylquinazolin-4-ol

Downstream raw materials:

6,7-dimethoxy-2-methyl-4-(4-nitro-phenoxy)-quinazoline

4-(6,7-dimethoxy-2-methyl-quinazolin-4-yloxy)-phenylamine

N-(4-fluorophenyl)-N'-(4-{[2-methyl-6,7-bis(methyloxy)quinazolin-4-yl]oxy}phenyl)cyclopropane-1,1-dicarboxamide