4-[(2S,3R)-2-Benzyloxycarbonyl-3-(1-tert-butoxycarbonyl-piperidin-3-ylmethyl)-4-oxo-azetidine-1-carbonyl]-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester

Base Information

• Chemical Name: 4-[(2S,3R)-2-Benzyloxycarbonyl-3-(1-tert-butoxycarbonyl-piperidin-3-ylmethyl)-4-oxo-azetidine-1-carbonyl]-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester
• CAS No.: 253177-07-0
• Molecular Formula: C₃₅H₅₂N₄O₈
• Molecular Weight: 656.82
• Mol file: 253177-07-0.mol

Synonyms:

Chemical Property of 4-[(2S,3R)-2-Benzyloxycarbonyl-3-(1-tert-butoxycarbonyl-piperidin-3-ylmethyl)-4-oxo-azetidine-1-carbonyl]-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[(2S,3R)-2-Benzyloxycarbonyl-3-(1-tert-butoxycarbonyl-piperidin-3-ylmethyl)-4-oxo-azetidine-1-carbonyl]-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester

There total 1 articles about 4-[(2S,3R)-2-Benzyloxycarbonyl-3-(1-tert-butoxycarbonyl-piperidin-3-ylmethyl)-4-oxo-azetidine-1-carbonyl]-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-diisopropylmethoxycarbonylpiperazine-4-carbonylchloride (253177-45-6) + 3-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester (253177-06-9) → 4-[(2S,3R)-2-Benzyloxycarbonyl-3-(1-tert-butoxycarbonyl-piperidin-3-ylmethyl)-4-oxo-azetidine-1-carbonyl]-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester (253177-07-0)

Guidance literature:

With dmap; TEA; In N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2004.02.011

Reference yield:

4-[(2S,3R)-2-Benzyloxycarbonyl-3-(1-tert-butoxycarbonyl-piperidin-3-ylmethyl)-4-oxo-azetidine-1-carbonyl]-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester (253177-07-0) → C2HF3O2*C30H44N4O6

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

4-[(2S,3R)-2-Benzyloxycarbonyl-3-(1-tert-butoxycarbonyl-piperidin-3-ylmethyl)-4-oxo-azetidine-1-carbonyl]-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester (253177-07-0) → 4-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-3-piperidin-3-ylmethyl-azetidine-1-carbonyl)-piperazine-1-carboxylic acid 1-isopropyl-2-methyl-propyl ester

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2004.02.011

upstream raw materials:

1-diisopropylmethoxycarbonylpiperazine-4-carbonylchloride

3-((2S,3R)-2-Benzyloxycarbonyl-4-oxo-azetidin-3-ylmethyl)-piperidine-1-carboxylic acid tert-butyl ester