(2-AMINO-2-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: (2-AMINO-2-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER
• CAS No.: 95034-05-2
• Molecular Formula: C9H20N2O2
• Molecular Weight: 188.27
• Hs Code.: 2924199090
• Mol file: 95034-05-2.mol

Synonyms:(2-AMINO-2-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER;TERT-BUTYL 2-AMINO-2-METHYLPROPYLCARBAMATE

Chemical Property of (2-AMINO-2-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

• Boiling Point: 275.1±23.0 °C(Predicted)
• PKA: 13.42±0.46(Predicted)
• PSA: 67.84000
• Density: 0.974±0.06 g/cm3(Predicted)
• LogP: 2.15310
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl(2-Amino-2-methylpropyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2-AMINO-2-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER

There total 5 articles about (2-AMINO-2-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyl phenyl carbonate (6627-89-0) + 1,1-dimethylethylenediamine (811-93-8) → tert-butyl (2-amino-2-methylpropyl)carbamate (95034-05-2)

Guidance literature:

In ethanol; Heating;

DOI:10.1055/s-2002-34859

Reference yield: 86.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,1-dimethylethylenediamine (811-93-8) → tert-butyl (2-amino-2-methylpropyl)carbamate (95034-05-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 80.0%

tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate (13139-12-3) + 1,1-dimethylethylenediamine (811-93-8) → tert-butyl (2-amino-2-methylpropyl)carbamate (95034-05-2)

Guidance literature:

In dichloromethane; 1.) -40 deg C, 3 h, 2.) -40 deg C to r.t., overnight;

DOI:10.1080/00304949809355294

upstream raw materials:

tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate

1,1-dimethylethylenediamine

di-tert-butyl dicarbonate

tert-butyl phenyl carbonate

Downstream raw materials:

tert-butyl N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]carbamate

C₃₀H₄₁BrN₄O₃

Z-Gly-Dadme-Boc

Refernces

• 1、 -. "ALKYLBORONIC ACIDS AS ARGINASE INHIBITORS". Page/Page column 103. . Retrieved 2020/08/22.
• 2、 -. "HETEROCYCLIC COMPOUNDS AS ARGINASE INHIBITORS". Page/Page column 69. . Retrieved 2019/07/13.