tert-Butyl (2-amino-2-methylpropyl)carbamate

Base Information

• Chemical Name: tert-Butyl (2-amino-2-methylpropyl)carbamate
• CAS No.: 95034-05-2
• Molecular Formula: C9H20N2O2
• Molecular Weight: 188.27
• Hs Code.: 2924199090
• European Community (EC) Number: 825-651-5
• DSSTox Substance ID: DTXSID60591565
• Nikkaji Number: J1.822.084I
• Wikidata: Q82485359
• Mol file: 95034-05-2.mol

Synonyms:95034-05-2;tert-Butyl (2-amino-2-methylpropyl)carbamate;tert-butyl N-(2-amino-2-methylpropyl)carbamate;tert-butyl 2-amino-2-methylpropylcarbamate;(2-AMINO-2-METHYL-PROPYL)-CARBAMIC ACID TERT-BUTYL ESTER;MFCD11040212;N1-Boc-2-methyl-1,2-propanediamine;SCHEMBL854272;(2-amino-2-methylpropyl)carbamic acid tert-butyl ester;DTXSID60591565;KCBBEHBEAPOBSC-UHFFFAOYSA-N;VDA03405;Carbamic acid, (2-amino-2-methylpropyl)-, 1,1-dimethylethyl ester;AKOS006283671;SB40187;AMY202003247;BS-13868;SY186730;DB-080166;tert-Butyl(2-amino-2-methylpropyl)carbamate;EN300-68883;t-butyl (2-amino-2-methyl-1-propyl)carbamate;tert-Butyl (2-Amino-2-methylpropyl)-carbamate;tert-butyl N-(2-amino-2-methyl-propyl)carbamate;n-(2-amino-2-methylpropyl)(tert-butoxy)carboxamide;Z1083217742

Chemical Property of tert-Butyl (2-amino-2-methylpropyl)carbamate

Chemical Property:

• Boiling Point: 275.1±23.0 °C(Predicted)
• PKA: 13.42±0.46(Predicted)
• PSA: 67.84000
• Density: 0.974±0.06 g/cm3(Predicted)
• LogP: 2.15310
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 188.152477885
• Heavy Atom Count: 13
• Complexity: 183

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl(2-Amino-2-methylpropyl)carbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCC(C)(C)N

Technology Process of tert-Butyl (2-amino-2-methylpropyl)carbamate

There total 5 articles about tert-Butyl (2-amino-2-methylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

tert-butyl phenyl carbonate (6627-89-0) + 1,1-dimethylethylenediamine (811-93-8) → tert-butyl (2-amino-2-methylpropyl)carbamate (95034-05-2)

Guidance literature:

In ethanol; Heating;

DOI:10.1055/s-2002-34859

Reference yield: 86.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,1-dimethylethylenediamine (811-93-8) → tert-butyl (2-amino-2-methylpropyl)carbamate (95034-05-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 24h;

Reference yield: 80.0%

tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate (13139-12-3) + 1,1-dimethylethylenediamine (811-93-8) → tert-butyl (2-amino-2-methylpropyl)carbamate (95034-05-2)

Guidance literature:

In dichloromethane; 1.) -40 deg C, 3 h, 2.) -40 deg C to r.t., overnight;

DOI:10.1080/00304949809355294

upstream raw materials:

tert-butyl 2,5-dioxopyrrolidin-1-yl carbonate

1,1-dimethylethylenediamine

di-tert-butyl dicarbonate

tert-butyl phenyl carbonate

Downstream raw materials:

(S)-2-(2-tert-Butoxycarbonylamino-1,1-dimethyl-ethylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester

1-(tert-butyloxycarbamido)-2-[2,3-di(isopropylmercapto)benzamido]-2,2'-dimethylethane

C₂₇H₃₅N₃O₅

{(1S,2S)-1-Benzyl-3-[(S)-2-(2-tert-butoxycarbonylamino-1,1-dimethyl-ethylcarbamoyl)-pyrrolidin-1-yl]-2-hydroxy-3-oxo-propyl}-carbamic acid benzyl ester