4-IODO (1H)INDAZOLE

Base Information

• Chemical Name: 4-IODO (1H)INDAZOLE
• CAS No.: 885522-11-2
• Molecular Formula: C7H5IN2
• Molecular Weight: 244.03
• Hs Code.: 2933998090
• Mol file: 885522-11-2.mol

Synonyms:1H-indazole, 4-iodo-;4-Iodo-1H-indazole;LogP

Chemical Property of 4-IODO (1H)INDAZOLE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 208℃
• Refractive Index: 1.788
• Boiling Point: 358.187 °C at 760 mmHg
• PKA: 12.96±0.40(Predicted)
• Flash Point: 170.426 °C
• PSA: 28.68000
• Density: 2.083 g/cm³
• LogP: 2.16750
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

4-Iodo-1H-indazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-IODO (1H)INDAZOLE

There total 5 articles about 4-IODO (1H)INDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

3-iodo-2-methylphenyldiazonium tetrafluoroborate → 4-iodo-1H-indazole (885522-11-2)

Guidance literature:

With 18-crown-6 ether; potassium acetate; In chloroform; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2007.03.024

Reference yield: 34.0%

6-fluoro-2-iodobenzaldehyde (146137-72-6) → 4-iodo-1H-indazole (885522-11-2)

Guidance literature:

With hydrazine hydrate; at 120 ℃; for 2h;

DOI:10.1021/jm061280h

Reference yield: 25.0%

4-aminoindazole (41748-71-4) → 4-iodo-1H-indazole (885522-11-2)

Guidance literature:

4-aminoindazole; With hydrogenchloride; sodium nitrite; In water; at -10 ℃; for 0.5 - 1h;

With potassium iodide; In water; at 30 - 40 ℃; for 1.5 - 1.66667h;

upstream raw materials:

6-fluoro-2-iodobenzaldehyde

4-aminoindazole

nitro-4 indazole

3-nitro-o-tolylamine