6-Benzyl-6,7-dihydropyrrolo[3,4-b]pyridin-5-one

Base Information

• Chemical Name: 6-Benzyl-6,7-dihydropyrrolo[3,4-b]pyridin-5-one
• CAS No.: 109439-42-1
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.262
• DSSTox Substance ID: DTXSID60431851
• Wikidata: Q82245848
• Mol file: 109439-42-1.mol

Synonyms:109439-42-1;6-Benzyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one;6-benzyl-6,7-dihydropyrrolo[3,4-b]pyridin-5-one;6-benzyl-7H-pyrrolo[3,4-b]pyridin-5-one;SCHEMBL7692116;DTXSID60431851;5h-pyrrolo[3,4-b]pyridin-5-one,6,7-dihydro-6-(phenylmethyl)-

Chemical Property of 6-Benzyl-6,7-dihydropyrrolo[3,4-b]pyridin-5-one

Chemical Property:

• PSA: 33.20000
• LogP: 2.17550
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 224.094963011
• Heavy Atom Count: 17
• Complexity: 286

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C=CC=N2)C(=O)N1CC3=CC=CC=C3

Technology Process of 6-Benzyl-6,7-dihydropyrrolo[3,4-b]pyridin-5-one

There total 5 articles about 6-Benzyl-6,7-dihydropyrrolo[3,4-b]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione (18184-75-3) → 6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (109439-42-1)

Guidance literature:

With ethanol; tetrabutylammonium tetrafluoroborate; diisopropylamine; at 20 ℃; for 5h; chemoselective reaction; Electrochemical reaction; Schlenk technique; Green chemistry;

DOI:10.1021/acs.orglett.1c00430

Reference yield: 29.0%

6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione (18184-75-3) → 6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-7-one (1046121-24-7) + 6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (109439-42-1)

Guidance literature:

6-benzyl-5H-pyrrolo[3,4–b]pyridine-5,7(6H)-dione; With diphenylsilane; potassium hydroxide; In N,N-dimethyl-formamide; at 25 ℃; for 3h; Inert atmosphere; Schlenk technique;

With ammonium hydroxide; In water; N,N-dimethyl-formamide; at 20 ℃; for 1h; chemoselective reaction;

DOI:10.1002/adsc.201501093

Reference yield:

benzylamine (100-46-9) → 6-benzyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one (109439-42-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / 17 h / 120 °C

2: tetrabutylammonium tetrafluoroborate; diisopropylamine; ethanol / 5 h / 20 °C / Electrochemical reaction; Schlenk technique; Green chemistry

With ethanol; tetrabutylammonium tetrafluoroborate; acetic acid; diisopropylamine;

DOI:10.1021/acs.orglett.1c00430

upstream raw materials:

6-benzyl-5H-pyrrolo[3,4-b]pyridine-5,7(6H)-dione

benzylamine

Pyridine-2,3-dicarboxylic anhydride