3-(3-FLUORO-PHENYL)-QUINOLINE

Base Information

• Chemical Name: 3-(3-FLUORO-PHENYL)-QUINOLINE
• CAS No.: 181421-88-5
• Molecular Formula: C₁₅H₁₀FN
• Molecular Weight: 223.25
• Mol file: 181421-88-5.mol

Synonyms:

Chemical Property of 3-(3-FLUORO-PHENYL)-QUINOLINE

Chemical Property:

Purity/Quality:

3-(3-Fluorophenyl)quinoline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-FLUORO-PHENYL)-QUINOLINE

There total 9 articles about 3-(3-FLUORO-PHENYL)-QUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1-[quinolin-1(2H)-yl]ethan-1-one (10174-55-7) + 3-fluorophenylboronic acid (768-35-4) → 3-(3-fluorophenyl)quinoline (181421-88-5)

Guidance literature:

With palladium diacetate; copper(II) bis(trifluoromethanesulfonate); silver(l) oxide; In toluene; at 110 ℃; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/ol401349a

Reference yield: 70.0%

1-ethynyl-3-fluoro-benzene (2561-17-3) + dimethyl sulfoxide (67-68-5,8070-53-9) + aniline (62-53-3) → 3-(3-fluorophenyl)quinoline (181421-88-5)

Guidance literature:

With carbonyl(pentamethylcyclopentadienyl)cobalt diiodide; trifluoroacetic acid; silver(I) triflimide; at 120 ℃; for 24h; regioselective reaction;

DOI:10.1002/adsc.201801709

Reference yield:

3-(3-fluorophenyl)quinoline-4-carboxylic acid → 3-(3-fluorophenyl)quinoline (181421-88-5)

Guidance literature:

3-(3-fluorophenyl)quinoline-4-carboxylic acid; With trifluorormethanesulfonic acid; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h; Molecular sieve;

With copper(I) oxide; 1,10-Phenanthroline; In N,N-dimethyl-formamide; at 145 ℃; for 48h; Molecular sieve; Inert atmosphere; Microwave irradiation;

DOI:10.1021/acs.orglett.6b03085

upstream raw materials:

1-Fluoro-3-iodobenzene

N-[2-(3,3-Diethoxy-prop-1-ynyl)-phenyl]-acetamide

o-iodoacetanilide

3-fluorophenol