(1,6-dioxo-5-phenyl-12-pyrrolidino-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepin-3-ylmethylsulfanyl)acetic acid

Base Information

Chemical Name:(1,6-dioxo-5-phenyl-12-pyrrolidino-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepin-3-ylmethylsulfanyl)acetic acid
CAS No.:1272379-74-4
Molecular Formula:C₂₄H₂₉N₅O₄S
Molecular Weight:483.591
Hs Code.:

(1,6-dioxo-5-phenyl-12-pyrrolidino-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepin-3-ylmethylsulfanyl)acetic acid

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Chemical Property of (1,6-dioxo-5-phenyl-12-pyrrolidino-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepin-3-ylmethylsulfanyl)acetic acid

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Technology Process of (1,6-dioxo-5-phenyl-12-pyrrolidino-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepin-3-ylmethylsulfanyl)acetic acid

There total 4 articles about (1,6-dioxo-5-phenyl-12-pyrrolidino-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepin-3-ylmethylsulfanyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.9%

: 1272379-72-2
5-phenyl-12-(pyrrolidin-1-yl)-3-sulfanylmethyl-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

: 79-11-8
chloroacetic acid

: 1272379-74-4
(1,6-dioxo-5-phenyl-12-pyrrolidino-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepin-3-ylmethylsulfanyl)acetic acid

Guidance literature:: With potassium hydroxide; In ethanol; for 8h; Reflux;
DOI:10.1007/s00044-010-9545-5

Reference yield:

: C₁₆H₁₇ClN₄O

: 1272379-74-4
(1,6-dioxo-5-phenyl-12-pyrrolidino-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepin-3-ylmethylsulfanyl)acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol

2: sodium tetrahydroborate / ethanol

3: triethylamine / benzene / 2 h / 70 °C

4: thiourea / ethanol / 3 h / Reflux

5: potassium hydroxide / ethanol / 8 h / Reflux

With sodium tetrahydroborate; triethylamine; thiourea; potassium hydroxide; In ethanol; benzene;
DOI:10.1007/s00044-010-9545-5

Reference yield:

: 1233944-05-2
3-amino-1-oxo-2-phenyl-5-(pyrrolidin-1-yl)-1,2,4a,5,6,7,8,9-octahydropyrimido[1,6-a]azepine-4-carbonitrile

: 1272379-74-4
(1,6-dioxo-5-phenyl-12-pyrrolidino-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepin-3-ylmethylsulfanyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / benzene / 2 h / 70 °C

2: thiourea / ethanol / 3 h / Reflux

3: potassium hydroxide / ethanol / 8 h / Reflux

With triethylamine; thiourea; potassium hydroxide; In ethanol; benzene;
DOI:10.1007/s00044-010-9545-5